The human gastrointestinal microbiota and prostate cancer development and treatment

Sybil Sha, Liqiang Ni, Maria Stefil, Matthew Dixon, Vladimir Mouraviev

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)
2 Downloads (Pure)

Abstract

The human gastrointestinal microbiome contains commensal bacteria and other microbiota that have been gaining increasing attention in the context of cancer development and response to treatment. Microbiota play a role in the maintenance of host barrier surfaces that contribute to both local inflammation and other systemic metabolic functions. In the context of prostate cancer, the gastrointestinal microbiome may play a role through metabolism of estrogen, an increase of which has been linked to the induction of prostatic neoplasia. Specific microbiota such as Bacteroides, Streptococcus, Bacteroides massiliensis, Faecalibacterium prausnitzii, Eubacterium rectalie, and Mycoplasma genitalium have been associated with differing risks of prostate cancer development or extensiveness of prostate cancer disease. In this Review, we discuss gastrointestinal microbiota’s effects on prostate cancer development, the ability of the microbiome to regulate chemotherapy for prostate cancer treatment, and the importance of using Next Generation Sequencing to further discern the microbiome’s systemic influence on prostate cancer.

Original languageEnglish
Pages (from-to)S43-S50
Number of pages8
JournalInvestigative and Clinical Urology
Volume61
Issue numberSuppl 1
DOIs
Publication statusPublished - 1 Feb 2020

Keywords

  • Microbiota
  • Prostatic neoplasms

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