The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes

Phillppe J. Rocques; Jeremy Clark; Sarah Ball; Jayne Crew; Sandra Gill; Zoe Christodoulou; Rhona H. Borts; Edward J. Louis; Kay E. Davies; Colin S. Cooper

doi:10.1093/hmg/4.2.243

The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes

Phillppe J. Rocques, Jeremy Clark, Sarah Ball, Jayne Crew, Sandra Gill, Zoe Christodoulou, Rhona H. Borts, Edward J. Louis, Kay E. Davies, Colin S. Cooper

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

We report that the human gene SB1.8 (DXS423E) encodes a protein of 1233 amino acids that is highly homologous (30% Identity) to the essential yeast protein SMC1 which is required for the segregation of chromosomes at mitosis. Both SB1.8 and SMC1 contain an N-terminal NTP binding site, a central coiled-coil region and a C-terminal helix-loop-helix domain, and have structural features in common with the force generating proteins myosin and kinesin. SB1.8 also exhibits regions of homology and overall structural similarity to the prokaryote (Mycoplasma hyorhinis) protein 115p. Thus SB1.8 and SMC1 are members of a highly conserved and ubiquitous family of proteins that appear to have a fundamental role In cell division. In addition we show that SB1.8 (DXS423E) maps to a cosmid contig that lies centromeric to the OATL2 locus at chromosome Xp11.2.

Original language	English
Pages (from-to)	243-249
Number of pages	7
Journal	Human Molecular Genetics
Volume	4
Issue number	2
DOIs	https://doi.org/10.1093/hmg/4.2.243
Publication status	Published - 1 Feb 1995

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@article{a67ff3a8bba14d6083eec06ac27a7614,

title = "The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes",

abstract = "We report that the human gene SB1.8 (DXS423E) encodes a protein of 1233 amino acids that is highly homologous (30% Identity) to the essential yeast protein SMC1 which is required for the segregation of chromosomes at mitosis. Both SB1.8 and SMC1 contain an N-terminal NTP binding site, a central coiled-coil region and a C-terminal helix-loop-helix domain, and have structural features in common with the force generating proteins myosin and kinesin. SB1.8 also exhibits regions of homology and overall structural similarity to the prokaryote (Mycoplasma hyorhinis) protein 115p. Thus SB1.8 and SMC1 are members of a highly conserved and ubiquitous family of proteins that appear to have a fundamental role In cell division. In addition we show that SB1.8 (DXS423E) maps to a cosmid contig that lies centromeric to the OATL2 locus at chromosome Xp11.2.",

author = "Rocques, {Phillppe J.} and Jeremy Clark and Sarah Ball and Jayne Crew and Sandra Gill and Zoe Christodoulou and Borts, {Rhona H.} and Louis, {Edward J.} and Davies, {Kay E.} and Cooper, {Colin S.}",

note = "Funding Information: We would like to thank the Cancer Research Campaign and Medical Research Council for supporting this work and Christine Bell for typing the manuscript. PJR was supported by an MRC studentship. RHB and EJL are Wellcome Senior Fellows.",

year = "1995",

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doi = "10.1093/hmg/4.2.243",

language = "English",

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T1 - The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes

AU - Rocques, Phillppe J.

AU - Clark, Jeremy

AU - Ball, Sarah

AU - Crew, Jayne

AU - Gill, Sandra

AU - Christodoulou, Zoe

AU - Borts, Rhona H.

AU - Louis, Edward J.

AU - Davies, Kay E.

AU - Cooper, Colin S.

N1 - Funding Information: We would like to thank the Cancer Research Campaign and Medical Research Council for supporting this work and Christine Bell for typing the manuscript. PJR was supported by an MRC studentship. RHB and EJL are Wellcome Senior Fellows.

PY - 1995/2/1

Y1 - 1995/2/1

N2 - We report that the human gene SB1.8 (DXS423E) encodes a protein of 1233 amino acids that is highly homologous (30% Identity) to the essential yeast protein SMC1 which is required for the segregation of chromosomes at mitosis. Both SB1.8 and SMC1 contain an N-terminal NTP binding site, a central coiled-coil region and a C-terminal helix-loop-helix domain, and have structural features in common with the force generating proteins myosin and kinesin. SB1.8 also exhibits regions of homology and overall structural similarity to the prokaryote (Mycoplasma hyorhinis) protein 115p. Thus SB1.8 and SMC1 are members of a highly conserved and ubiquitous family of proteins that appear to have a fundamental role In cell division. In addition we show that SB1.8 (DXS423E) maps to a cosmid contig that lies centromeric to the OATL2 locus at chromosome Xp11.2.

AB - We report that the human gene SB1.8 (DXS423E) encodes a protein of 1233 amino acids that is highly homologous (30% Identity) to the essential yeast protein SMC1 which is required for the segregation of chromosomes at mitosis. Both SB1.8 and SMC1 contain an N-terminal NTP binding site, a central coiled-coil region and a C-terminal helix-loop-helix domain, and have structural features in common with the force generating proteins myosin and kinesin. SB1.8 also exhibits regions of homology and overall structural similarity to the prokaryote (Mycoplasma hyorhinis) protein 115p. Thus SB1.8 and SMC1 are members of a highly conserved and ubiquitous family of proteins that appear to have a fundamental role In cell division. In addition we show that SB1.8 (DXS423E) maps to a cosmid contig that lies centromeric to the OATL2 locus at chromosome Xp11.2.

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JO - Human Molecular Genetics

JF - Human Molecular Genetics

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ER -

The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes

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