The influence of reduced susceptibility to fluoroquinolones in Salmonella enterica serovar Typhi on the clinical response to ofloxacin therapy

Christopher M. Parry; Ha Vinh; Nguyen Tran Chinh; John Wain; James I. Campbell; Tran Tinh Hien; Jeremy J. Farrar; Stephen Baker

doi:10.1371/journal.pntd.0001163

The influence of reduced susceptibility to fluoroquinolones in Salmonella enterica serovar Typhi on the clinical response to ofloxacin therapy

Christopher M. Parry, Ha Vinh, Nguyen Tran Chinh, John Wain, James I. Campbell, Tran Tinh Hien, Jeremy J. Farrar, Stephen Baker

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Background: Infection with Salmonella enterica serovar Typhi (S. Typhi) with reduced susceptibility to fluoroquinolones has been associated with fluoroquinolone treatment failure. We studied the relationship between ofloxacin treatment response and the ofloxacin minimum inhibitory concentration (MIC) of the infecting isolate. Individual patient data from seven randomised controlled trials of antimicrobial treatment in enteric fever conducted in Vietnam in which ofloxacin was used in at least one of the treatment arms was studied. Data from 540 patients randomised to ofloxacin treatment was analysed to identify an MIC of the infecting organism associated with treatment failure. Principal Findings: The proportion of patients failing ofloxacin treatment was significantly higher in patients infected with S. Typhi isolates with an MIC=0.25 µg/mL compared with those infections with an MIC of =0.125 µg/mL (p

Original language	English
Article number	e1163
Journal	PLoS Neglected Tropical Diseases
Volume	5
Issue number	6
DOIs	https://doi.org/10.1371/journal.pntd.0001163
Publication status	Published - Jun 2011

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10.1371/journal.pntd.0001163Licence: CC BY

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title = "The influence of reduced susceptibility to fluoroquinolones in Salmonella enterica serovar Typhi on the clinical response to ofloxacin therapy",

abstract = "Background: Infection with Salmonella enterica serovar Typhi (S. Typhi) with reduced susceptibility to fluoroquinolones has been associated with fluoroquinolone treatment failure. We studied the relationship between ofloxacin treatment response and the ofloxacin minimum inhibitory concentration (MIC) of the infecting isolate. Individual patient data from seven randomised controlled trials of antimicrobial treatment in enteric fever conducted in Vietnam in which ofloxacin was used in at least one of the treatment arms was studied. Data from 540 patients randomised to ofloxacin treatment was analysed to identify an MIC of the infecting organism associated with treatment failure. Principal Findings: The proportion of patients failing ofloxacin treatment was significantly higher in patients infected with S. Typhi isolates with an MIC=0.25 µg/mL compared with those infections with an MIC of =0.125 µg/mL (p",

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AU - Parry, Christopher M.

AU - Vinh, Ha

AU - Chinh, Nguyen Tran

AU - Wain, John

AU - Campbell, James I.

AU - Hien, Tran Tinh

AU - Farrar, Jeremy J.

AU - Baker, Stephen

N1 - © 2011 Parry et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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N2 - Background: Infection with Salmonella enterica serovar Typhi (S. Typhi) with reduced susceptibility to fluoroquinolones has been associated with fluoroquinolone treatment failure. We studied the relationship between ofloxacin treatment response and the ofloxacin minimum inhibitory concentration (MIC) of the infecting isolate. Individual patient data from seven randomised controlled trials of antimicrobial treatment in enteric fever conducted in Vietnam in which ofloxacin was used in at least one of the treatment arms was studied. Data from 540 patients randomised to ofloxacin treatment was analysed to identify an MIC of the infecting organism associated with treatment failure. Principal Findings: The proportion of patients failing ofloxacin treatment was significantly higher in patients infected with S. Typhi isolates with an MIC=0.25 µg/mL compared with those infections with an MIC of =0.125 µg/mL (p

AB - Background: Infection with Salmonella enterica serovar Typhi (S. Typhi) with reduced susceptibility to fluoroquinolones has been associated with fluoroquinolone treatment failure. We studied the relationship between ofloxacin treatment response and the ofloxacin minimum inhibitory concentration (MIC) of the infecting isolate. Individual patient data from seven randomised controlled trials of antimicrobial treatment in enteric fever conducted in Vietnam in which ofloxacin was used in at least one of the treatment arms was studied. Data from 540 patients randomised to ofloxacin treatment was analysed to identify an MIC of the infecting organism associated with treatment failure. Principal Findings: The proportion of patients failing ofloxacin treatment was significantly higher in patients infected with S. Typhi isolates with an MIC=0.25 µg/mL compared with those infections with an MIC of =0.125 µg/mL (p

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