The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver

Rinke Stienstra, Stéphane Mandard, Nguan Soon Tan, Walter Wahli, Christian Trautwein, Terrilyn A Richardson, Elgin Lichtenauer-Kaligis, Sander Kersten, Michael Müller

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


The Peroxisome Proliferator-Activated Receptor (PPAR) alpha belongs to the superfamily of Nuclear Receptors and plays an important role in numerous cellular processes, including lipid metabolism. It is known that PPARalpha also has an anti-inflammatory effect, which is mainly achieved by down-regulating pro-inflammatory genes. The objective of this study was to further characterize the role of PPARalpha in inflammatory gene regulation in liver.
Original languageEnglish
Pages (from-to)869-77
Number of pages9
JournalJournal of Hepatology
Issue number5
Publication statusPublished - May 2007


  • Animals
  • Anticholesteremic Agents
  • Carcinoma, Hepatocellular
  • Female
  • Gene Expression Regulation
  • Hepatitis
  • Hepatocytes
  • Humans
  • Hypoglycemic Agents
  • Interleukin 1 Receptor Antagonist Protein
  • Liver
  • Male
  • Mice
  • Mice, Knockout
  • PPAR alpha
  • Promoter Regions, Genetic
  • Pyrimidines
  • RNA, Messenger
  • Receptors, Interleukin-1 Type I
  • Thiazolidinediones
  • Transcription Factors
  • Transcription, Genetic
  • Transcriptional Activation
  • Tumor Cells, Cultured
  • Up-Regulation

Cite this