The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver

Rinke Stienstra; Stéphane Mandard; Nguan Soon Tan; Walter Wahli; Christian Trautwein; Terrilyn A Richardson; Elgin Lichtenauer-Kaligis; Sander Kersten; Michael Müller

doi:10.1016/j.jhep.2006.11.019

The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver

Rinke Stienstra, Stéphane Mandard, Nguan Soon Tan, Walter Wahli, Christian Trautwein, Terrilyn A Richardson, Elgin Lichtenauer-Kaligis, Sander Kersten, Michael Müller

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

The Peroxisome Proliferator-Activated Receptor (PPAR) alpha belongs to the superfamily of Nuclear Receptors and plays an important role in numerous cellular processes, including lipid metabolism. It is known that PPARalpha also has an anti-inflammatory effect, which is mainly achieved by down-regulating pro-inflammatory genes. The objective of this study was to further characterize the role of PPARalpha in inflammatory gene regulation in liver.

Original language	English
Pages (from-to)	869-77
Number of pages	9
Journal	Journal of Hepatology
Volume	46
Issue number	5
DOIs	https://doi.org/10.1016/j.jhep.2006.11.019
Publication status	Published - May 2007

Keywords

Animals
Anticholesteremic Agents
Carcinoma, Hepatocellular
Female
Gene Expression Regulation
Hepatitis
Hepatocytes
Humans
Hypoglycemic Agents
Interleukin 1 Receptor Antagonist Protein
Liver
Male
Mice
Mice, Knockout
PPAR alpha
Promoter Regions, Genetic
Pyrimidines
RNA, Messenger
Receptors, Interleukin-1 Type I
Thiazolidinediones
Transcription Factors
Transcription, Genetic
Transcriptional Activation
Tumor Cells, Cultured
Up-Regulation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jhep.2006.11.019

Cite this

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title = "The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver",

abstract = "The Peroxisome Proliferator-Activated Receptor (PPAR) alpha belongs to the superfamily of Nuclear Receptors and plays an important role in numerous cellular processes, including lipid metabolism. It is known that PPARalpha also has an anti-inflammatory effect, which is mainly achieved by down-regulating pro-inflammatory genes. The objective of this study was to further characterize the role of PPARalpha in inflammatory gene regulation in liver.",

keywords = "Animals, Anticholesteremic Agents, Carcinoma, Hepatocellular, Female, Gene Expression Regulation, Hepatitis, Hepatocytes, Humans, Hypoglycemic Agents, Interleukin 1 Receptor Antagonist Protein, Liver, Male, Mice, Mice, Knockout, PPAR alpha, Promoter Regions, Genetic, Pyrimidines, RNA, Messenger, Receptors, Interleukin-1 Type I, Thiazolidinediones, Transcription Factors, Transcription, Genetic, Transcriptional Activation, Tumor Cells, Cultured, Up-Regulation",

author = "Rinke Stienstra and St{\'e}phane Mandard and Tan, {Nguan Soon} and Walter Wahli and Christian Trautwein and Richardson, {Terrilyn A} and Elgin Lichtenauer-Kaligis and Sander Kersten and Michael M{\"u}ller",

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volume = "46",

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T1 - The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver

AU - Stienstra, Rinke

AU - Mandard, Stéphane

AU - Tan, Nguan Soon

AU - Wahli, Walter

AU - Trautwein, Christian

AU - Richardson, Terrilyn A

AU - Lichtenauer-Kaligis, Elgin

AU - Kersten, Sander

AU - Müller, Michael

PY - 2007/5

Y1 - 2007/5

N2 - The Peroxisome Proliferator-Activated Receptor (PPAR) alpha belongs to the superfamily of Nuclear Receptors and plays an important role in numerous cellular processes, including lipid metabolism. It is known that PPARalpha also has an anti-inflammatory effect, which is mainly achieved by down-regulating pro-inflammatory genes. The objective of this study was to further characterize the role of PPARalpha in inflammatory gene regulation in liver.

AB - The Peroxisome Proliferator-Activated Receptor (PPAR) alpha belongs to the superfamily of Nuclear Receptors and plays an important role in numerous cellular processes, including lipid metabolism. It is known that PPARalpha also has an anti-inflammatory effect, which is mainly achieved by down-regulating pro-inflammatory genes. The objective of this study was to further characterize the role of PPARalpha in inflammatory gene regulation in liver.

KW - Animals

KW - Anticholesteremic Agents

KW - Carcinoma, Hepatocellular

KW - Female

KW - Gene Expression Regulation

KW - Hepatitis

KW - Hepatocytes

KW - Humans

KW - Hypoglycemic Agents

KW - Interleukin 1 Receptor Antagonist Protein

KW - Liver

KW - Male

KW - Mice

KW - Mice, Knockout

KW - PPAR alpha

KW - Promoter Regions, Genetic

KW - Pyrimidines

KW - RNA, Messenger

KW - Receptors, Interleukin-1 Type I

KW - Thiazolidinediones

KW - Transcription Factors

KW - Transcription, Genetic

KW - Transcriptional Activation

KW - Tumor Cells, Cultured

KW - Up-Regulation

U2 - 10.1016/j.jhep.2006.11.019

DO - 10.1016/j.jhep.2006.11.019

M3 - Article

C2 - 17321000

VL - 46

SP - 869

EP - 877

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 5

ER -