The leptin receptor Gln223Arg polymorphism (rs1137101) mediates the postprandial lipaemic response, but only in males

Kim G Jackson, Javier Delgado-Lista, Rosalynn Gill, Julie A Lovegrove, Christine M Williams, Jose López-Miranda, Anne-Marie Minihane

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


An exaggerated postprandial triacylglycerol (TAG) response is an important determinant of cardiovascular disease risk. With increased recognition of the role of leptin in systemic macronutrient metabolism, we used a candidate gene approach to examine the impact of the common leptin receptor (LEPR) Gln223Arg polymorphism (rs1137101) on postprandial lipaemia.
Original languageEnglish
Pages (from-to)135-41
Number of pages7
Issue number1
Publication statusPublished - Nov 2012


  • Adult
  • Aged
  • Fasting
  • Female
  • Humans
  • Lipids
  • Male
  • Metabolic Syndrome X
  • Middle Aged
  • Polymorphism, Genetic
  • Postprandial Period
  • Receptors, Leptin
  • Triglycerides

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