The leptin receptor Gln223Arg polymorphism (rs1137101) mediates the postprandial lipaemic response, but only in males

Kim G Jackson; Javier Delgado-Lista; Rosalynn Gill; Julie A Lovegrove; Christine M Williams; Jose López-Miranda; Anne-Marie Minihane

doi:10.1016/j.atherosclerosis.2012.08.035

The leptin receptor Gln223Arg polymorphism (rs1137101) mediates the postprandial lipaemic response, but only in males

Kim G Jackson, Javier Delgado-Lista, Rosalynn Gill, Julie A Lovegrove, Christine M Williams, Jose López-Miranda, Anne-Marie Minihane

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

An exaggerated postprandial triacylglycerol (TAG) response is an important determinant of cardiovascular disease risk. With increased recognition of the role of leptin in systemic macronutrient metabolism, we used a candidate gene approach to examine the impact of the common leptin receptor (LEPR) Gln223Arg polymorphism (rs1137101) on postprandial lipaemia.

Original language	English
Pages (from-to)	135-41
Number of pages	7
Journal	Atherosclerosis
Volume	225
Issue number	1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2012.08.035
Publication status	Published - Nov 2012

Keywords

Adult
Aged
Fasting
Female
Humans
Lipids
Male
Metabolic Syndrome X
Middle Aged
Polymorphism, Genetic
Postprandial Period
Receptors, Leptin
Triglycerides

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.atherosclerosis.2012.08.035

Cite this

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title = "The leptin receptor Gln223Arg polymorphism (rs1137101) mediates the postprandial lipaemic response, but only in males",

abstract = "An exaggerated postprandial triacylglycerol (TAG) response is an important determinant of cardiovascular disease risk. With increased recognition of the role of leptin in systemic macronutrient metabolism, we used a candidate gene approach to examine the impact of the common leptin receptor (LEPR) Gln223Arg polymorphism (rs1137101) on postprandial lipaemia.",

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AU - Lovegrove, Julie A

AU - Williams, Christine M

AU - López-Miranda, Jose

AU - Minihane, Anne-Marie

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KW - Aged

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KW - Humans

KW - Lipids

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KW - Metabolic Syndrome X

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KW - Postprandial Period

KW - Receptors, Leptin

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