The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity

Thierry Halter, Julia Imkampe, Sara Mazzotta, Michael Wierzba, Sandra Postel, Christoph Bücherl, Christian Kiefer, Mark Stahl, Delphine Chinchilla, Xiaofeng Wang, Thorsten Nürnberger, Cyril Zipfel, Steven Clouse, Jan Willem Borst, Sjef Boeren, Sacco C de Vries, Frans Tax, Birgit Kemmerling

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192 Citations (Scopus)


Transmembrane leucine-rich repeat (LRR) receptors are commonly used innate immune receptors in plants and animals but can also sense endogenous signals to regulate development. BAK1 is a plant LRR-receptor-like kinase (RLK) that interacts with several ligand-binding LRR-RLKs to positively regulate their functions. BAK1 is involved in brassinosteroid-dependent growth and development, innate immunity, and cell-death control by interacting with the brassinosteroid receptor BRI1, immune receptors, such as FLS2 and EFR, and the small receptor kinase BIR1, respectively.
Original languageEnglish
Pages (from-to)134-143
Number of pages10
JournalCurrent Biology
Issue number2
Publication statusPublished - 20 Jan 2014

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