The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity

Thierry Halter; Julia Imkampe; Sara Mazzotta; Michael Wierzba; Sandra Postel; Christoph Bücherl; Christian Kiefer; Mark Stahl; Delphine Chinchilla; Xiaofeng Wang; Thorsten Nürnberger; Cyril Zipfel; Steven Clouse; Jan Willem Borst; Sjef Boeren; Sacco C de Vries; Frans Tax; Birgit Kemmerling

doi:10.1016/j.cub.2013.11.047

The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity

Thierry Halter
, Julia Imkampe
, Sara Mazzotta
, Michael Wierzba
, Sandra Postel
, Christoph Bücherl
, Christian Kiefer
, Mark Stahl
, Delphine Chinchilla
, Xiaofeng Wang
, Thorsten Nürnberger
, Cyril Zipfel
, Steven Clouse
, Jan Willem Borst
, Sjef Boeren
, Sacco C de Vries
, Frans Tax
, Birgit Kemmerling

Research output: Contribution to journal › Article › peer-review

238 Citations (Scopus)

Abstract

Transmembrane leucine-rich repeat (LRR) receptors are commonly used innate immune receptors in plants and animals but can also sense endogenous signals to regulate development. BAK1 is a plant LRR-receptor-like kinase (RLK) that interacts with several ligand-binding LRR-RLKs to positively regulate their functions. BAK1 is involved in brassinosteroid-dependent growth and development, innate immunity, and cell-death control by interacting with the brassinosteroid receptor BRI1, immune receptors, such as FLS2 and EFR, and the small receptor kinase BIR1, respectively.

Original language	English
Pages (from-to)	134-143
Number of pages	10
Journal	Current Biology
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.cub.2013.11.047
Publication status	Published - 20 Jan 2014

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10.1016/j.cub.2013.11.047

Cyril Zipfel
- C.Zipfeluea.acuk
- The Sainsbury Laboratory - Senior Scientist (TSL)
- Plant Sciences - Member
Person: Research Group Member, Academic, Teaching and Research (NBI)

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Halter, T., Imkampe, J., Mazzotta, S., Wierzba, M., Postel, S., Bücherl, C., Kiefer, C., Stahl, M., Chinchilla, D., Wang, X., Nürnberger, T., Zipfel, C., Clouse, S., Borst, J. W., Boeren, S., de Vries, S. C., Tax, F., & Kemmerling, B. (2014). The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity. Current Biology, 24(2), 134-143. https://doi.org/10.1016/j.cub.2013.11.047

@article{a45261e8e3f84afcba112b0b9f86c769,

title = "The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity",

abstract = "Transmembrane leucine-rich repeat (LRR) receptors are commonly used innate immune receptors in plants and animals but can also sense endogenous signals to regulate development. BAK1 is a plant LRR-receptor-like kinase (RLK) that interacts with several ligand-binding LRR-RLKs to positively regulate their functions. BAK1 is involved in brassinosteroid-dependent growth and development, innate immunity, and cell-death control by interacting with the brassinosteroid receptor BRI1, immune receptors, such as FLS2 and EFR, and the small receptor kinase BIR1, respectively.",

author = "Thierry Halter and Julia Imkampe and Sara Mazzotta and Michael Wierzba and Sandra Postel and Christoph B{\"u}cherl and Christian Kiefer and Mark Stahl and Delphine Chinchilla and Xiaofeng Wang and Thorsten N{\"u}rnberger and Cyril Zipfel and Steven Clouse and Borst, \{Jan Willem\} and Sjef Boeren and \{de Vries\}, \{Sacco C\} and Frans Tax and Birgit Kemmerling",

year = "2014",

month = jan,

day = "20",

doi = "10.1016/j.cub.2013.11.047",

language = "English",

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journal = "Current Biology",

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Halter, T, Imkampe, J, Mazzotta, S, Wierzba, M, Postel, S, Bücherl, C, Kiefer, C, Stahl, M, Chinchilla, D, Wang, X, Nürnberger, T, Zipfel, C, Clouse, S, Borst, JW, Boeren, S, de Vries, SC, Tax, F & Kemmerling, B 2014, 'The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity', Current Biology, vol. 24, no. 2, pp. 134-143. https://doi.org/10.1016/j.cub.2013.11.047

TY - JOUR

T1 - The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity

AU - Halter, Thierry

AU - Imkampe, Julia

AU - Mazzotta, Sara

AU - Wierzba, Michael

AU - Postel, Sandra

AU - Bücherl, Christoph

AU - Kiefer, Christian

AU - Stahl, Mark

AU - Chinchilla, Delphine

AU - Wang, Xiaofeng

AU - Nürnberger, Thorsten

AU - Zipfel, Cyril

AU - Clouse, Steven

AU - Borst, Jan Willem

AU - Boeren, Sjef

AU - de Vries, Sacco C

AU - Tax, Frans

AU - Kemmerling, Birgit

PY - 2014/1/20

Y1 - 2014/1/20

N2 - Transmembrane leucine-rich repeat (LRR) receptors are commonly used innate immune receptors in plants and animals but can also sense endogenous signals to regulate development. BAK1 is a plant LRR-receptor-like kinase (RLK) that interacts with several ligand-binding LRR-RLKs to positively regulate their functions. BAK1 is involved in brassinosteroid-dependent growth and development, innate immunity, and cell-death control by interacting with the brassinosteroid receptor BRI1, immune receptors, such as FLS2 and EFR, and the small receptor kinase BIR1, respectively.

AB - Transmembrane leucine-rich repeat (LRR) receptors are commonly used innate immune receptors in plants and animals but can also sense endogenous signals to regulate development. BAK1 is a plant LRR-receptor-like kinase (RLK) that interacts with several ligand-binding LRR-RLKs to positively regulate their functions. BAK1 is involved in brassinosteroid-dependent growth and development, innate immunity, and cell-death control by interacting with the brassinosteroid receptor BRI1, immune receptors, such as FLS2 and EFR, and the small receptor kinase BIR1, respectively.

U2 - 10.1016/j.cub.2013.11.047

DO - 10.1016/j.cub.2013.11.047

M3 - Article

C2 - 24388849

SN - 0960-9822

VL - 24

SP - 134

EP - 143

JO - Current Biology

JF - Current Biology

IS - 2

ER -

The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity

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Cyril Zipfel

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