The malignancy grading method is not a reliable assessment of malignancy in mesothelioma

G. Tierney, M. J. Wilkinson, J. S. P. Jones

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6 Citations (Scopus)


The ploidy of a series of pleural lesions--reactive proliferations, malignant mesotheliomas and metastatic tumours--was measured on a Leitz Miamed DNA image analyser using Feulgen-stained slides. The technique successfully recognized all the metastatic tumours as malignant; this corresponds to previous work. However, it was not successful in classifying mesothelial lesions as benign or malignant, resulting in a very high false-negative rate and a moderately high false-positive rate. Mesothelial lesions appear to have a wide range of ploidy values irrespective of their biological behaviour. Thus, for primary mesothelial tumours, the ploidy value cannot be used as a reliable diagnostic index.

Original languageEnglish
Pages (from-to)209-211
Number of pages3
JournalThe Journal of Pathology
Issue number3
Publication statusPublished - Mar 1990


  • False Negative Reactions
  • False Positive Reactions
  • Humans
  • Mesothelioma
  • Pleural Neoplasms
  • Ploidies

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