The oesophageal microbiome and cancer: Hope or hype?

Bhaskar Kumar; Stephen Lam; Mina Adam; Rachel Gilroy; Mark J. Pallen

doi:10.1016/j.tim.2021.08.007

The oesophageal microbiome and cancer: Hope or hype?

Bhaskar Kumar, Stephen Lam, Mina Adam, Rachel Gilroy, Mark J. Pallen

Norwich Medical School

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

7 Downloads (Pure)

Abstract

The human oesophagus is home to a complex microbial community, the oesophageal microbiome. Despite decades of work, we still have only a poor, low-resolution view of this community, which makes it hard to distinguish hope from hype when it comes to assessing links between the oesophageal microbiome and cancer. Here we review the potential importance of this microbiome and discuss new approaches, including culturomics, metagenomics, and recovery of whole-genome sequences, that bring renewed hope for an in-depth characterisation of this community that could deliver translational impact.

Original language	English
Pages (from-to)	322-329
Number of pages	8
Journal	Trends in Microbiology
Volume	30
Issue number	4
Early online date	4 Sep 2021
DOIs	https://doi.org/10.1016/j.tim.2021.08.007
Publication status	Published - Apr 2022

Keywords

Barrett's oesophagus
gastro-oesophageal reflux
microbiome
oesophageal adenocarcinoma
oesophageal squamous cell carcinoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tim.2021.08.007

Accepted_ManuscriptAccepted author manuscript, 236 KBLicence: CC BY-NC-ND

Cite this

@article{d26b7d0e9b164120b86e943471c203b1,

title = "The oesophageal microbiome and cancer: Hope or hype?",

abstract = "The human oesophagus is home to a complex microbial community, the oesophageal microbiome. Despite decades of work, we still have only a poor, low-resolution view of this community, which makes it hard to distinguish hope from hype when it comes to assessing links between the oesophageal microbiome and cancer. Here we review the potential importance of this microbiome and discuss new approaches, including culturomics, metagenomics, and recovery of whole-genome sequences, that bring renewed hope for an in-depth characterisation of this community that could deliver translational impact.",

keywords = "Barrett's oesophagus, gastro-oesophageal reflux, microbiome, oesophageal adenocarcinoma, oesophageal squamous cell carcinoma",

author = "Bhaskar Kumar and Stephen Lam and Mina Adam and Rachel Gilroy and Pallen, {Mark J.}",

note = "Funding Information: M.J.P. is supported by the Quadram Institute Bioscience BBSRC-funded Strategic Program: Microbes in the Food Chain (project no. BB/R012504/1 ) and its constituent project BBS/E/F/000PR10351 (Theme 3, Microbial Communities in the Food Chain). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2022",

month = apr,

doi = "10.1016/j.tim.2021.08.007",

language = "English",

volume = "30",

pages = "322--329",

journal = "Trends in Microbiology",

issn = "0966-842X",