Abstract
Cip/Kip proteins that inhibit cyclin-dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and subsequent initiation of replication is co-ordinately regulated at, and localized to, replication origins.
Original language | English |
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Pages (from-to) | E182-E184 |
Number of pages | 3 |
Journal | Nature Cell Biology |
Volume | 3 |
Issue number | 8 |
DOIs |
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Publication status | Published - Aug 2001 |