The origin of CDK regulation

Anatoliy Li, J. Julian Blow

Research output: Contribution to journalComment/debatepeer-review

47 Citations (Scopus)


Cip/Kip proteins that inhibit cyclin-dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and subsequent initiation of replication is co-ordinately regulated at, and localized to, replication origins.
Original languageEnglish
Pages (from-to)E182-E184
Number of pages3
JournalNature Cell Biology
Issue number8
Publication statusPublished - Aug 2001

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