The origin of CDK regulation

Anatoliy Li; J. Julian Blow

doi:10.1038/35087119

The origin of CDK regulation

Anatoliy Li, J. Julian Blow

Research output: Contribution to journal › Comment/debate › peer-review

49 Citations (Scopus)

Abstract

Cip/Kip proteins that inhibit cyclin-dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and subsequent initiation of replication is co-ordinately regulated at, and localized to, replication origins.

Original language	English
Pages (from-to)	E182-E184
Number of pages	3
Journal	Nature Cell Biology
Volume	3
Issue number	8
DOIs	https://doi.org/10.1038/35087119
Publication status	Published - Aug 2001

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10.1038/35087119

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title = "The origin of CDK regulation",

abstract = "Cip/Kip proteins that inhibit cyclin-dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and subsequent initiation of replication is co-ordinately regulated at, and localized to, replication origins.",

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AB - Cip/Kip proteins that inhibit cyclin-dependent kinase 2 (Cdk2) restrain the initiation of DNA replication. Degradation of a Xenopus Kip1 orthologue, Xic1, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and subsequent initiation of replication is co-ordinately regulated at, and localized to, replication origins.

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M3 - Comment/debate

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