The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion

Yu Ting Tan; Frauke Wenzelburger; Eveline Lee; Grant Heatlie; Francisco Leyva; Kiran Patel; Michael Frenneaux; John E Sanderson

doi:10.1016/j.jacc.2009.03.037

The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion

Yu Ting Tan, Frauke Wenzelburger, Eveline Lee, Grant Heatlie, Francisco Leyva, Kiran Patel, Michael Frenneaux, John E Sanderson

Research output: Contribution to journal › Article › peer-review

416 Citations (Scopus)

Abstract

The purpose of this study was to test the hypothesis that in heart failure with normal ejection fraction (HFNEF) exercise limitation is due to combined systolic and diastolic abnormalities, particularly involving ventricular twist and deformation (strain) leading to reduced ventricular suction, delayed untwisting, and impaired early diastolic filling.

Original language	English
Pages (from-to)	36-46
Number of pages	11
Journal	Journal of the American College of Cardiology
Volume	54
Issue number	1
Early online date	23 Jun 2009
DOIs	https://doi.org/10.1016/j.jacc.2009.03.037
Publication status	Published - 30 Jun 2009

Keywords

diastolic
heart failure
rotation
strain
untwist
socialisation

Access to Document

10.1016/j.jacc.2009.03.037

Cite this

Tan, Y. T., Wenzelburger, F., Lee, E., Heatlie, G., Leyva, F., Patel, K., Frenneaux, M., & Sanderson, J. E. (2009). The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion. Journal of the American College of Cardiology, 54(1), 36-46. https://doi.org/10.1016/j.jacc.2009.03.037

Tan, Yu Ting ; Wenzelburger, Frauke ; Lee, Eveline et al. / The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion. In: Journal of the American College of Cardiology. 2009 ; Vol. 54, No. 1. pp. 36-46.

@article{357bf77233164e358877af862edd96e2,

title = "The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion",

abstract = "The purpose of this study was to test the hypothesis that in heart failure with normal ejection fraction (HFNEF) exercise limitation is due to combined systolic and diastolic abnormalities, particularly involving ventricular twist and deformation (strain) leading to reduced ventricular suction, delayed untwisting, and impaired early diastolic filling.",

keywords = "diastolic, heart failure, rotation, strain, untwist, socialisation",

author = "Tan, {Yu Ting} and Frauke Wenzelburger and Eveline Lee and Grant Heatlie and Francisco Leyva and Kiran Patel and Michael Frenneaux and Sanderson, {John E}",

year = "2009",

month = jun,

day = "30",

doi = "10.1016/j.jacc.2009.03.037",

language = "English",

volume = "54",

pages = "36--46",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier",

number = "1",

}

Tan, YT, Wenzelburger, F, Lee, E, Heatlie, G, Leyva, F, Patel, K, Frenneaux, M & Sanderson, JE 2009, 'The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion', Journal of the American College of Cardiology, vol. 54, no. 1, pp. 36-46. https://doi.org/10.1016/j.jacc.2009.03.037

The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion. / Tan, Yu Ting; Wenzelburger, Frauke; Lee, Eveline et al.

In: Journal of the American College of Cardiology, Vol. 54, No. 1, 30.06.2009, p. 36-46.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion

AU - Tan, Yu Ting

AU - Wenzelburger, Frauke

AU - Lee, Eveline

AU - Heatlie, Grant

AU - Leyva, Francisco

AU - Patel, Kiran

AU - Frenneaux, Michael

AU - Sanderson, John E

PY - 2009/6/30

Y1 - 2009/6/30

N2 - The purpose of this study was to test the hypothesis that in heart failure with normal ejection fraction (HFNEF) exercise limitation is due to combined systolic and diastolic abnormalities, particularly involving ventricular twist and deformation (strain) leading to reduced ventricular suction, delayed untwisting, and impaired early diastolic filling.

AB - The purpose of this study was to test the hypothesis that in heart failure with normal ejection fraction (HFNEF) exercise limitation is due to combined systolic and diastolic abnormalities, particularly involving ventricular twist and deformation (strain) leading to reduced ventricular suction, delayed untwisting, and impaired early diastolic filling.

KW - diastolic

KW - heart failure

KW - rotation

KW - strain

KW - untwist

KW - socialisation

U2 - 10.1016/j.jacc.2009.03.037

DO - 10.1016/j.jacc.2009.03.037

M3 - Article

C2 - 19555838

VL - 54

SP - 36

EP - 46

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 1

ER -

Tan YT, Wenzelburger F, Lee E, Heatlie G, Leyva F, Patel K et al. The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion. Journal of the American College of Cardiology. 2009 Jun 30;54(1):36-46. Epub 2009 Jun 23. doi: 10.1016/j.jacc.2009.03.037