The People with Asperger syndrome and anxiety disorders (PAsSA) trial: A pilot multicentre, single-blind randomised trial of group cognitive–behavioural therapy

Peter Langdon; Glynis Murphy; Lee Shepstone; Edward Wilson; David Fowler; David Heavens; Aida Malovic; Alexandra Russell; Alice Rose; Louise Mullineaux

doi:10.1192/bjpo.bp.115.002527

The People with Asperger syndrome and anxiety disorders (PAsSA) trial: A pilot multicentre, single-blind randomised trial of group cognitive–behavioural therapy

Peter Langdon (Lead Author), Glynis Murphy, Lee Shepstone, Edward Wilson, David Fowler, David Heavens, Aida Malovic, Alexandra Russell, Alice Rose, Louise Mullineaux

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: There is a growing interest in using cognitive–behavioural therapy (CBT) with people who have Asperger syndrome and comorbid mental health problems.

Aims: To examine whether modified group CBT for clinically significant anxiety in an Asperger syndrome population is feasible and likely to be efficacious.

Method: Using a randomised assessor-blind trial, 52 individuals with Asperger syndrome were randomised into a treatment arm or a waiting-list control arm. After 24 weeks, those in the waiting-list control arm received treatment, while those initially randomised to treatment were followed up for 24 weeks.

Results: The conversion rate for this trial was high (1.6:1), while attrition was 13%. After 24 weeks, there was no significant difference between those randomised to the treatment arm compared with those randomised to the waiting-list control arm on the primary outcome measure, the Hamilton Rating Scale for Anxiety.

Conclusions: Trials of psychological therapies with this population are feasible. Larger definitive trials are now needed.

Original language	English
Pages (from-to)	179-186
Number of pages	8
Journal	BJPsych Open
Volume	2
Issue number	2
DOIs	https://doi.org/10.1192/bjpo.bp.115.002527
Publication status	Published - 13 Apr 2016

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Cite this

Langdon, P., Murphy, G., Shepstone, L., Wilson, E., Fowler, D., Heavens, D., Malovic, A., Russell, A., Rose, A., & Mullineaux, L. (2016). The People with Asperger syndrome and anxiety disorders (PAsSA) trial: A pilot multicentre, single-blind randomised trial of group cognitive–behavioural therapy. BJPsych Open, 2(2), 179-186. https://doi.org/10.1192/bjpo.bp.115.002527

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abstract = "Background: There is a growing interest in using cognitive–behavioural therapy (CBT) with people who have Asperger syndrome and comorbid mental health problems. Aims: To examine whether modified group CBT for clinically significant anxiety in an Asperger syndrome population is feasible and likely to be efficacious. Method: Using a randomised assessor-blind trial, 52 individuals with Asperger syndrome were randomised into a treatment arm or a waiting-list control arm. After 24 weeks, those in the waiting-list control arm received treatment, while those initially randomised to treatment were followed up for 24 weeks. Results: The conversion rate for this trial was high (1.6:1), while attrition was 13%. After 24 weeks, there was no significant difference between those randomised to the treatment arm compared with those randomised to the waiting-list control arm on the primary outcome measure, the Hamilton Rating Scale for Anxiety. Conclusions: Trials of psychological therapies with this population are feasible. Larger definitive trials are now needed.",

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Langdon, P, Murphy, G, Shepstone, L, Wilson, E, Fowler, D, Heavens, D, Malovic, A, Russell, A, Rose, A & Mullineaux, L 2016, 'The People with Asperger syndrome and anxiety disorders (PAsSA) trial: A pilot multicentre, single-blind randomised trial of group cognitive–behavioural therapy', BJPsych Open, vol. 2, no. 2, pp. 179-186. https://doi.org/10.1192/bjpo.bp.115.002527

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AU - Langdon, Peter

AU - Murphy, Glynis

AU - Shepstone, Lee

AU - Wilson, Edward

AU - Fowler, David

AU - Heavens, David

AU - Malovic, Aida

AU - Russell, Alexandra

AU - Rose, Alice

AU - Mullineaux, Louise

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