The Pfam protein families database

Alex Bateman, Lachlan Coin, Richard Durbin, Robert D Finn, Volker Hollich, Sam Griffiths-Jones, Ajay Khanna, Mhairi Marshall, Simon Moxon, Erik L L Sonnhammer, David J Studholme, Corin Yeats, Sean R Eddy

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Pfam is a large collection of protein families and domains. Over the past 2 years the number of families in Pfam has doubled and now stands at 6190 (version 10.0). Methodology improvements for searching the Pfam collection locally as well as via the web are described. Other recent innovations include modelling of discontinuous domains allowing Pfam domain definitions to be closer to those found in structure databases. Pfam is available on the web in the UK (, the USA (, France ( and Sweden (

Original languageEnglish
Pages (from-to)D138-D141
Number of pages4
JournalNucleic Acids Research
Issue numberSuppl 1
Publication statusPublished - 2004

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