The physiology of the circadian rhythm of parathyroid hormone and its potential as a treatment for osteoporosis

William D Fraser, Aftab M Ahmad, Jiten P Vora

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40 Citations (Scopus)


The circadian nature of parathyroid hormone secretion is confirmed by many publications. The underlying rhythm is endogenous. Life style factors and nutritional intake modulate the pattern of secretion. Direct association with bone resorption and formation is tentative. It is suggested that acute changes in these rhythms have little effect on resorption, but longer-term manipulation of parathyroid hormone secretion alters bone cell function. Growth hormone therapy in adult deficiency increases parathyroid hormone activity, indicating growth hormone may have therapeutic potential for osteoporosis. Manipulation of the endogenous parathyroid hormone rhythm, using timed supplements of phosphate or calcium or by calcilytic and calcimimetic molecules, offers a novel approach to osteoporosis treatment.
Original languageEnglish
Pages (from-to)437-444
Number of pages8
JournalCurrent Opinion in Nephrology and Hypertension
Issue number4
Publication statusPublished - 2004

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