The plant immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector

Ming Yu Wang, Jun Bin Chen, Rui Wu, Hai Long Guo, Yan Chen, Zhen Ju Li, Lu Yang Wei, Chuang Liu, Sheng Feng He, Mei Da Du, Ya long Guo, You Liang Peng, Jonathan D. G. Jones, Detlef Weigel, Jian-Hua Huang, Wang Sheng Zhu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Plants deploy intracellular receptors to counteract pathogen effectors that suppress cell-surface-receptor-mediated immunity. To what extent pathogens manipulate intracellular receptor-mediated immunity, and how plants tackle such manipulation, remains unknown. Arabidopsis thaliana encodes three similar ADR1 class helper nucleotide-binding domain leucine-rich repeat receptors (ADR1, ADR1-L1, and ADR1-L2), which are crucial in plant immunity initiated by intracellular receptors. Here, we report that Pseudomonas syringae effector AvrPtoB suppresses ADR1-L1- and ADR1-L2-mediated cell death. ADR1, however, evades such suppression by diversifying into two ubiquitination sites targeted by AvrPtoB. The intracellular sensor SNC1 interacts with and guards the CCR domains of ADR1-L1/L2. Removal of ADR1-L1/L2 or delivery of AvrPtoB activates SNC1, which then signals through ADR1 to trigger immunity. Our work elucidates the long-sought-after function of SNC1 in defense, and also how plants can use dual strategies, sequence diversification, and a multi-layered guard-guardee system, to counteract pathogen's attack on core immunity functions.

Original languageEnglish
Pages (from-to)1792-1803.e7
Number of pages12
JournalCell Host and Microbe
Volume31
Issue number11
DOIs
Publication statusPublished - 8 Nov 2023

Keywords

  • ADR1s
  • E3 ubiquitin ligase
  • effector-triggered immunity
  • helper NLRs
  • plant and microbe interactions
  • plant immunity
  • Pseudomonas effector
  • SNC1

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