@article{a7d869edb9fe4edcadc6e48745572f95,
title = "The plant immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector",
abstract = "Plants deploy intracellular receptors to counteract pathogen effectors that suppress cell-surface-receptor-mediated immunity. To what extent pathogens manipulate intracellular receptor-mediated immunity, and how plants tackle such manipulation, remains unknown. Arabidopsis thaliana encodes three similar ADR1 class helper nucleotide-binding domain leucine-rich repeat receptors (ADR1, ADR1-L1, and ADR1-L2), which are crucial in plant immunity initiated by intracellular receptors. Here, we report that Pseudomonas syringae effector AvrPtoB suppresses ADR1-L1- and ADR1-L2-mediated cell death. ADR1, however, evades such suppression by diversifying into two ubiquitination sites targeted by AvrPtoB. The intracellular sensor SNC1 interacts with and guards the CCR domains of ADR1-L1/L2. Removal of ADR1-L1/L2 or delivery of AvrPtoB activates SNC1, which then signals through ADR1 to trigger immunity. Our work elucidates the long-sought-after function of SNC1 in defense, and also how plants can use dual strategies, sequence diversification, and a multi-layered guard-guardee system, to counteract pathogen's attack on core immunity functions.",
keywords = "ADR1s, E3 ubiquitin ligase, effector-triggered immunity, helper NLRs, plant and microbe interactions, plant immunity, Pseudomonas effector, SNC1",
author = "Wang, \{Ming Yu\} and Chen, \{Jun Bin\} and Rui Wu and Guo, \{Hai Long\} and Yan Chen and Li, \{Zhen Ju\} and Wei, \{Lu Yang\} and Chuang Liu and He, \{Sheng Feng\} and Du, \{Mei Da\} and Guo, \{Ya long\} and Peng, \{You Liang\} and Jones, \{Jonathan D. G.\} and Detlef Weigel and Jian-Hua Huang and Zhu, \{Wang Sheng\}",
note = "Funding Information: R.W. was supported by the EU Horizon 2020 research and innovation program under the Marie Sk{\l}odowska-Curie scheme (H2020-MSCA-IF-2014-655295). J.D.G.J. was supported by the Gatsby Foundation (UK). D.W. was supported by ERC-SyG PATHOCOM 951444 and the Max Planck Society. J.-H.H. was supported by the EUs Horizon 2020 research and innovation program under the Marie Sk{\l}odowska-Curie scheme (no 897584). W.-S.Z. was supported by the National Key Research and Development Program, Ministry of Science and Technology of China (no 2022YFD1201802), the Ministry of Education of China (the 111 Project B13006), and the 2115 Talent Development Program of China Agricultural University (no 2020RC013). Data and code availability: This study analyses existing, publicly available data and does not generate new datasets and sequences. Information on the publicly available data is listed in the key resources table. All data are provided in the main figures and supplemental figures. Original data have been deposited to Mendeley Data (https://doi.org/10.17632/ph4y2sjbhc.1): https://data.mendeley.com/datasets/ph4y2sjbhc/1.",
year = "2023",
month = nov,
day = "8",
doi = "10.1016/j.chom.2023.10.006",
language = "English",
volume = "31",
pages = "1792--1803.e7",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "11",
}