Abstract
With the identification and increasing understanding of the genes involved in neoplastic transformation has come the realization that abrogation of these genes' products may lead to cell death or a return to normalcy. The use of ribozymes and their nucleic acid cousins, antisense oligodeoxynucleotides (ODNs), are two such ways of perturbing the disease-related gene expression. This review will look at the development and application of ribozymes to abrogate gene expression, with particular relevance to hematological settings. Some examples of antisense ODNs will also be mentioned where appropriate.
| Original language | English |
|---|---|
| Pages (from-to) | 361-368 |
| Number of pages | 8 |
| Journal | Journal of Leukocyte Biology |
| Volume | 66 |
| Issue number | 3 |
| Publication status | Published - Sep 1999 |
Keywords
- Drug Resistance, Neoplasm
- Gene Expression Regulation
- Genetic Therapy
- Hematologic Diseases
- Hematologic Neoplasms
- Humans
- Immune System Diseases
- Nucleic Acid Conformation
- Oligonucleotides, Antisense
- Oncogene Proteins, Fusion
- Oncogenes
- RNA, Catalytic
- Virus Diseases
- Virus Replication