The potential application of ribozymes for the treatment of hematological disorders

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Abstract

With the identification and increasing understanding of the genes involved in neoplastic transformation has come the realization that abrogation of these genes' products may lead to cell death or a return to normalcy. The use of ribozymes and their nucleic acid cousins, antisense oligodeoxynucleotides (ODNs), are two such ways of perturbing the disease-related gene expression. This review will look at the development and application of ribozymes to abrogate gene expression, with particular relevance to hematological settings. Some examples of antisense ODNs will also be mentioned where appropriate.
Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalJournal of Leukocyte Biology
Volume66
Issue number3
Publication statusPublished - Sep 1999

Keywords

  • Drug Resistance, Neoplasm
  • Gene Expression Regulation
  • Genetic Therapy
  • Hematologic Diseases
  • Hematologic Neoplasms
  • Humans
  • Immune System Diseases
  • Nucleic Acid Conformation
  • Oligonucleotides, Antisense
  • Oncogene Proteins, Fusion
  • Oncogenes
  • RNA, Catalytic
  • Virus Diseases
  • Virus Replication

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