The potential influence of genetic variants in genes along bile acid and bile metabolic pathway on blood cholesterol levels in the population

Yingchang Lu, Edith J M Feskens, Jolanda M A Boer, Michael Müller

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

The liver is currently known to be the major organ to eliminate excess cholesterol from our body. It accomplishes this function in two ways: conversion of cholesterol molecules into bile acids (BAs) and secretion of unesterified cholesterol molecules into bile. BAs are synthesized in the hepatocytes, secreted into bile and delivered to the lumen of the small intestine where they act as detergents to facilitate absorption of fats and fat-soluble vitamins. About 95% of BAs are recovered in the ileum during each cycle of the enterohepatic circulation. Five percent are lost and replaced by newly synthesized BAs, which amounts to approximately 500 mg/day in adult humans. In contrast to the efficiency of the BAs' enterohepatic circulation, 50% of the 1000 mg of cholesterol secreted daily into bile is lost in feces. It is known that rare human mutations in certain genes in bile acid and bile metabolic pathway influence blood cholesterol levels. With the recent success of genome-wide association studies, we are convinced that common genetic variants also play a role in the genetic architecture of plasma lipid traits. In this review, we summarized the current state of knowledge about genetic variations in bile acid and bile metabolic pathway, and assessed their impact on blood cholesterol levels and cholesterol metabolic kinetics in the population.
Original languageEnglish
Pages (from-to)14-27
Number of pages14
JournalAtherosclerosis
Volume210
Issue number1
DOIs
Publication statusPublished - May 2010

Keywords

  • ATP-Binding Cassette Transporters
  • Bile Acids and Salts
  • Cholesterol
  • Cholesterol 7-alpha-Hydroxylase
  • Enterohepatic Circulation
  • Genetic Variation
  • Hepatocyte Nuclear Factor 4
  • Lipoproteins
  • Membrane Proteins
  • Orphan Nuclear Receptors

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