The progress of coronary heart disease in Type 2 diabetes as measured by coronary calcium score from electron beam computed tomography (EBCT): the PREDICT study

Robert S Elkeles; Ian F Godsland; Michael B Rubens; Michael D Feher; Fiona Nugara; Marcus D Flather

doi:10.1016/j.atherosclerosis.2007.07.016

The progress of coronary heart disease in Type 2 diabetes as measured by coronary calcium score from electron beam computed tomography (EBCT): the PREDICT study

Robert S Elkeles, Ian F Godsland, Michael B Rubens, Michael D Feher, Fiona Nugara, Marcus D Flather

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Coronary calcification score (CACS) measured by electron beam tomography is well established in the evaluation of cardiovascular risk in general populations. The PREDICT study aims to evaluate prediction of cardiovascular events by CACS in Type 2 diabetic subjects without previous clinical cardiovascular disease. In the present PREDICT sub-study, the rate of progression of CACS and factors influencing this rate were assessed. CACS was measured at baseline and after a mean interval of 4.0 (range of 2.1-5.0) years in the 202 PREDICT participants who agreed to have a second scan. Participants also had a range of conventional and novel biochemical risk factors measured at baseline. Progression of calcification was apparent in 170 (84%), while in 32 (16%) there was regression or no progression. Those showing progression had a significantly more adverse risk factor profile. Rate of change in CACS was strongly related to baseline CACS (p

Original language	English
Pages (from-to)	777-83
Number of pages	7
Journal	Atherosclerosis
Volume	197
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2007.07.016
Publication status	Published - Apr 2008

Keywords

Aged
Blood Pressure
Calcinosis
Coronary Artery Disease
Diabetes Mellitus, Type 2
Disease Progression
Female
Humans
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Risk Factors
Tomography, X-Ray Computed

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.atherosclerosis.2007.07.016

Cite this

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title = "The progress of coronary heart disease in Type 2 diabetes as measured by coronary calcium score from electron beam computed tomography (EBCT): the PREDICT study",

abstract = "Coronary calcification score (CACS) measured by electron beam tomography is well established in the evaluation of cardiovascular risk in general populations. The PREDICT study aims to evaluate prediction of cardiovascular events by CACS in Type 2 diabetic subjects without previous clinical cardiovascular disease. In the present PREDICT sub-study, the rate of progression of CACS and factors influencing this rate were assessed. CACS was measured at baseline and after a mean interval of 4.0 (range of 2.1-5.0) years in the 202 PREDICT participants who agreed to have a second scan. Participants also had a range of conventional and novel biochemical risk factors measured at baseline. Progression of calcification was apparent in 170 (84%), while in 32 (16%) there was regression or no progression. Those showing progression had a significantly more adverse risk factor profile. Rate of change in CACS was strongly related to baseline CACS (p",

keywords = "Aged, Blood Pressure, Calcinosis, Coronary Artery Disease, Diabetes Mellitus, Type 2, Disease Progression, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Risk Factors, Tomography, X-Ray Computed",

author = "Elkeles, {Robert S} and Godsland, {Ian F} and Rubens, {Michael B} and Feher, {Michael D} and Fiona Nugara and Flather, {Marcus D}",

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AU - Godsland, Ian F

AU - Rubens, Michael B

AU - Feher, Michael D

AU - Nugara, Fiona

AU - Flather, Marcus D

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N2 - Coronary calcification score (CACS) measured by electron beam tomography is well established in the evaluation of cardiovascular risk in general populations. The PREDICT study aims to evaluate prediction of cardiovascular events by CACS in Type 2 diabetic subjects without previous clinical cardiovascular disease. In the present PREDICT sub-study, the rate of progression of CACS and factors influencing this rate were assessed. CACS was measured at baseline and after a mean interval of 4.0 (range of 2.1-5.0) years in the 202 PREDICT participants who agreed to have a second scan. Participants also had a range of conventional and novel biochemical risk factors measured at baseline. Progression of calcification was apparent in 170 (84%), while in 32 (16%) there was regression or no progression. Those showing progression had a significantly more adverse risk factor profile. Rate of change in CACS was strongly related to baseline CACS (p

AB - Coronary calcification score (CACS) measured by electron beam tomography is well established in the evaluation of cardiovascular risk in general populations. The PREDICT study aims to evaluate prediction of cardiovascular events by CACS in Type 2 diabetic subjects without previous clinical cardiovascular disease. In the present PREDICT sub-study, the rate of progression of CACS and factors influencing this rate were assessed. CACS was measured at baseline and after a mean interval of 4.0 (range of 2.1-5.0) years in the 202 PREDICT participants who agreed to have a second scan. Participants also had a range of conventional and novel biochemical risk factors measured at baseline. Progression of calcification was apparent in 170 (84%), while in 32 (16%) there was regression or no progression. Those showing progression had a significantly more adverse risk factor profile. Rate of change in CACS was strongly related to baseline CACS (p

KW - Aged

KW - Blood Pressure

KW - Calcinosis

KW - Coronary Artery Disease

KW - Diabetes Mellitus, Type 2

KW - Disease Progression

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Risk Factors

KW - Tomography, X-Ray Computed

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DO - 10.1016/j.atherosclerosis.2007.07.016

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JF - Atherosclerosis

SN - 0021-9150

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