The provisional OMERACT ultrasonography score for giant cell arteritis

Christian Dejaco; Cristina Ponte; Sara Monti; Davide Rozza; Carlo Alberto Scirè; Lene Terslev; George A. W. Bruyn; Dennis Boumans; Wolfgang Hartung; Alojzija Hočevar; Marcin Milchert; Uffe Møller Døhn; Chetan B. Mukhtyar; Markus Aschwanden; Philipp Bosch; Dario Camellino; Stavros Chrysidis; Giovanni Ciancio; Maria Antonietta D'Agostino; Thomas Daikeler; Bhaskar Dasgupta; Eugenio De Miguel; Andreas P. Diamantopoulos; Christina Duftner; Ana Agueda; Ulrich Fredberg; Petra Hanova; Ib Tønder Hansen; Ellen Margrethe Hauge; Annamaria Iagnocco; Nevsun Inanc; Aaron Juche; Rositsa Karalilova; Toshio Kawamoto; Kresten Krarup Keller; Helen Isobel Keen; Tanaz A. Kermani; Minna J. Kohler; Matthew Koster; Raashid Ahmed Luqmani; Pierluigi Macchioni; Sarah Louise MacKie; Esperanza Naredo; Berit Dalsgaard Nielsen; Michihiro Ogasawara; Carlos Pineda; Valentin Sebastian Schäfer; Luca Seitz; Alessandro Tomelleri; Karina D. Torralba; Kornelis S. M. van der Geest; Kenneth J. Warrington; Wolfgang A. Schmidt

doi:10.1136/ard-2022-223367

The provisional OMERACT ultrasonography score for giant cell arteritis

Christian Dejaco, Cristina Ponte, Sara Monti, Davide Rozza, Carlo Alberto Scirè, Lene Terslev, George A. W. Bruyn, Dennis Boumans, Wolfgang Hartung, Alojzija Hočevar, Marcin Milchert, Uffe Møller Døhn, Chetan B. Mukhtyar, Markus Aschwanden, Philipp Bosch, Dario Camellino, Stavros Chrysidis, Giovanni Ciancio, Maria Antonietta D'Agostino, Thomas DaikelerBhaskar Dasgupta, Eugenio De Miguel, Andreas P. Diamantopoulos, Christina Duftner, Ana Agueda, Ulrich Fredberg, Petra Hanova, Ib Tønder Hansen, Ellen Margrethe Hauge, Annamaria Iagnocco, Nevsun Inanc, Aaron Juche, Rositsa Karalilova, Toshio Kawamoto, Kresten Krarup Keller, Helen Isobel Keen, Tanaz A. Kermani, Minna J. Kohler, Matthew Koster, Raashid Ahmed Luqmani, Pierluigi Macchioni, Sarah Louise MacKie, Esperanza Naredo, Berit Dalsgaard Nielsen, Michihiro Ogasawara, Carlos Pineda, Valentin Sebastian Schäfer, Luca Seitz, Alessandro Tomelleri, Karina D. Torralba, Kornelis S. M. van der Geest, Kenneth J. Warrington, Wolfgang A. Schmidt

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Abstract

Objectives: To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods: The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results: Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from-1.19 to-2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corrcoeff 0.37-0.48). Conclusion: We developed a provisional OGUS for potential use in clinical trials.

Original language	English
Article number	223367
Pages (from-to)	556-564
Number of pages	9
Journal	Annals of the Rheumatic Diseases
Volume	82
Issue number	4
Early online date	12 Dec 2022
DOIs	https://doi.org/10.1136/ard-2022-223367
Publication status	Published - Apr 2023
Externally published	Yes

Keywords

giant cell arteritis
outcome assessment, health care
systemic vasculitis
ultrasonography

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10.1136/ard-2022-223367

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Dejaco, C., Ponte, C., Monti, S., Rozza, D., Scirè, C. A., Terslev, L., Bruyn, G. A. W., Boumans, D., Hartung, W., Hočevar, A., Milchert, M., Døhn, U. M., Mukhtyar, C. B., Aschwanden, M., Bosch, P., Camellino, D., Chrysidis, S., Ciancio, G., D'Agostino, M. A., ... Schmidt, W. A. (2023). The provisional OMERACT ultrasonography score for giant cell arteritis. Annals of the Rheumatic Diseases, 82(4), 556-564. [223367]. https://doi.org/10.1136/ard-2022-223367

@article{bd71ebe0d52d43e08fc7a68054e1aea8,

title = "The provisional OMERACT ultrasonography score for giant cell arteritis",

abstract = "Objectives: To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods: The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results: Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from-1.19 to-2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corrcoeff 0.37-0.48). Conclusion: We developed a provisional OGUS for potential use in clinical trials. ",

keywords = "giant cell arteritis, outcome assessment, health care, systemic vasculitis, ultrasonography",

author = "Christian Dejaco and Cristina Ponte and Sara Monti and Davide Rozza and Scir{\`e}, {Carlo Alberto} and Lene Terslev and Bruyn, {George A. W.} and Dennis Boumans and Wolfgang Hartung and Alojzija Ho{\v c}evar and Marcin Milchert and D{\o}hn, {Uffe M{\o}ller} and Mukhtyar, {Chetan B.} and Markus Aschwanden and Philipp Bosch and Dario Camellino and Stavros Chrysidis and Giovanni Ciancio and D'Agostino, {Maria Antonietta} and Thomas Daikeler and Bhaskar Dasgupta and {De Miguel}, Eugenio and Diamantopoulos, {Andreas P.} and Christina Duftner and Ana Agueda and Ulrich Fredberg and Petra Hanova and Hansen, {Ib T{\o}nder} and Hauge, {Ellen Margrethe} and Annamaria Iagnocco and Nevsun Inanc and Aaron Juche and Rositsa Karalilova and Toshio Kawamoto and Keller, {Kresten Krarup} and Keen, {Helen Isobel} and Kermani, {Tanaz A.} and Kohler, {Minna J.} and Matthew Koster and Luqmani, {Raashid Ahmed} and Pierluigi Macchioni and MacKie, {Sarah Louise} and Esperanza Naredo and Nielsen, {Berit Dalsgaard} and Michihiro Ogasawara and Carlos Pineda and Sch{\"a}fer, {Valentin Sebastian} and Luca Seitz and Alessandro Tomelleri and Torralba, {Karina D.} and {van der Geest}, {Kornelis S. M.} and Warrington, {Kenneth J.} and Schmidt, {Wolfgang A.}",

year = "2023",

month = apr,

doi = "10.1136/ard-2022-223367",

language = "English",

volume = "82",

pages = "556--564",

journal = "Annals of the Rheumatic Diseases",

issn = "0003-4967",

publisher = "BMJ Publishing Group",

number = "4",

}

Dejaco, C, Ponte, C, Monti, S, Rozza, D, Scirè, CA, Terslev, L, Bruyn, GAW, Boumans, D, Hartung, W, Hočevar, A, Milchert, M, Døhn, UM, Mukhtyar, CB, Aschwanden, M, Bosch, P, Camellino, D, Chrysidis, S, Ciancio, G, D'Agostino, MA, Daikeler, T, Dasgupta, B, De Miguel, E, Diamantopoulos, AP, Duftner, C, Agueda, A, Fredberg, U, Hanova, P, Hansen, IT, Hauge, EM, Iagnocco, A, Inanc, N, Juche, A, Karalilova, R, Kawamoto, T, Keller, KK, Keen, HI, Kermani, TA, Kohler, MJ, Koster, M, Luqmani, RA, Macchioni, P, MacKie, SL, Naredo, E, Nielsen, BD, Ogasawara, M, Pineda, C, Schäfer, VS, Seitz, L, Tomelleri, A, Torralba, KD, van der Geest, KSM, Warrington, KJ & Schmidt, WA 2023, 'The provisional OMERACT ultrasonography score for giant cell arteritis', Annals of the Rheumatic Diseases, vol. 82, no. 4, 223367, pp. 556-564. https://doi.org/10.1136/ard-2022-223367

TY - JOUR

T1 - The provisional OMERACT ultrasonography score for giant cell arteritis

AU - Dejaco, Christian

AU - Ponte, Cristina

AU - Monti, Sara

AU - Rozza, Davide

AU - Scirè, Carlo Alberto

AU - Terslev, Lene

AU - Bruyn, George A. W.

AU - Boumans, Dennis

AU - Hartung, Wolfgang

AU - Hočevar, Alojzija

AU - Milchert, Marcin

AU - Døhn, Uffe Møller

AU - Mukhtyar, Chetan B.

AU - Aschwanden, Markus

AU - Bosch, Philipp

AU - Camellino, Dario

AU - Chrysidis, Stavros

AU - Ciancio, Giovanni

AU - D'Agostino, Maria Antonietta

AU - Daikeler, Thomas

AU - Dasgupta, Bhaskar

AU - De Miguel, Eugenio

AU - Diamantopoulos, Andreas P.

AU - Duftner, Christina

AU - Agueda, Ana

AU - Fredberg, Ulrich

AU - Hanova, Petra

AU - Hansen, Ib Tønder

AU - Hauge, Ellen Margrethe

AU - Iagnocco, Annamaria

AU - Inanc, Nevsun

AU - Juche, Aaron

AU - Karalilova, Rositsa

AU - Kawamoto, Toshio

AU - Keller, Kresten Krarup

AU - Keen, Helen Isobel

AU - Kermani, Tanaz A.

AU - Kohler, Minna J.

AU - Koster, Matthew

AU - Luqmani, Raashid Ahmed

AU - Macchioni, Pierluigi

AU - MacKie, Sarah Louise

AU - Naredo, Esperanza

AU - Nielsen, Berit Dalsgaard

AU - Ogasawara, Michihiro

AU - Pineda, Carlos

AU - Schäfer, Valentin Sebastian

AU - Seitz, Luca

AU - Tomelleri, Alessandro

AU - Torralba, Karina D.

AU - van der Geest, Kornelis S. M.

AU - Warrington, Kenneth J.

AU - Schmidt, Wolfgang A.

PY - 2023/4

Y1 - 2023/4

N2 - Objectives: To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods: The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results: Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from-1.19 to-2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corrcoeff 0.37-0.48). Conclusion: We developed a provisional OGUS for potential use in clinical trials.

AB - Objectives: To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods: The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results: Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from-1.19 to-2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corrcoeff 0.37-0.48). Conclusion: We developed a provisional OGUS for potential use in clinical trials.

KW - giant cell arteritis

KW - outcome assessment, health care

KW - systemic vasculitis

KW - ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=85144887883&partnerID=8YFLogxK

U2 - 10.1136/ard-2022-223367

DO - 10.1136/ard-2022-223367

M3 - Article

AN - SCOPUS:85144887883

VL - 82

SP - 556

EP - 564

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 4

M1 - 223367

ER -

The provisional OMERACT ultrasonography score for giant cell arteritis

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Keywords

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