The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling

Martin Stegmann; Jacqueline Monaghan; Elwira Smakowska-Luzan; Hanna Rovenich; Anita Lehner; Nicholas Holton; Youssef Belkhadir; Cyril Zipfel

doi:10.1126/science.aal2541

The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling

Martin Stegmann (Lead Author), Jacqueline Monaghan, Elwira Smakowska-Luzan, Hanna Rovenich, Anita Lehner, Nicholas Holton, Youssef Belkhadir, Cyril Zipfel

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Abstract

In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling. We show that FER acts as a RALF-regulated scaffold modulating receptor kinase complex assembly. A similar scaffolding mechanism may underlie RALF function in other signalling pathways.

Original language	English
Pages (from-to)	287-289
Number of pages	3
Journal	Science
Volume	355
Issue number	6322
DOIs	https://doi.org/10.1126/science.aal2541
Publication status	Published - 20 Jan 2017

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Accepted manuscriptAccepted author manuscript, 226 KBLicence: CC BY-NC

Cyril Zipfel
- C.Zipfeluea.acuk
- The Sainsbury Laboratory - Senior Scientist (TSL)
- Plant Sciences - Member
Person: Research Group Member, Academic, Teaching & Research

Cite this

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title = "The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling",

abstract = "In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling. We show that FER acts as a RALF-regulated scaffold modulating receptor kinase complex assembly. A similar scaffolding mechanism may underlie RALF function in other signalling pathways.",

author = "Martin Stegmann and Jacqueline Monaghan and Elwira Smakowska-Luzan and Hanna Rovenich and Anita Lehner and Nicholas Holton and Youssef Belkhadir and Cyril Zipfel",

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AU - Stegmann, Martin

AU - Monaghan, Jacqueline

AU - Smakowska-Luzan, Elwira

AU - Rovenich, Hanna

AU - Lehner, Anita

AU - Holton, Nicholas

AU - Belkhadir, Youssef

AU - Zipfel, Cyril

PY - 2017/1/20

Y1 - 2017/1/20

N2 - In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling. We show that FER acts as a RALF-regulated scaffold modulating receptor kinase complex assembly. A similar scaffolding mechanism may underlie RALF function in other signalling pathways.

AB - In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling. We show that FER acts as a RALF-regulated scaffold modulating receptor kinase complex assembly. A similar scaffolding mechanism may underlie RALF function in other signalling pathways.

U2 - 10.1126/science.aal2541

DO - 10.1126/science.aal2541

M3 - Article

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SP - 287

EP - 289

JO - Science

JF - Science

SN - 0036-8075

IS - 6322

ER -

The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling

Abstract

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Cyril Zipfel

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