The relationship between benign joint hypermobility syndrome and psychological distress: a systematic review and meta-analysis

Toby O Smith, Victoria Easton, Holly Bacon, Emma Jerman, Kate Armon, Fiona Poland, Alex J Macgregor, Alexander Macgregor

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)


Objective. This study examines the reported evidence of an association between benign joint hypermobility syndrome (BJHS) and psychological symptoms. Methods. A systematic review of published (AMED, CINAHL, MEDLINE, EMBASE, PubMed, Cochrane Library) and unpublished research databases (OpenGrey, the World Health Organization (WHO) International Clinical Trials Registry Platform, Current Controlled Trials, the UK National Research Register Archive) was performed from their inception to January 2013. Studies assessing the prevalence and incidence of psychological conditions for people diagnosed with BJHS were included. Meta-analysis assessing the odds ratio (OR) and standardized mean difference in severity of psychological conditions was performed. Methodological quality was assessed using the Critical Appraisal Skills Programme (CASP) appraisal tools. Results. Fourteen papers including 3957 participants, 1006 people with and 2951 controls without BJHS were eligible. The overall methodological quality was moderate. The results indicated that people with BJHS experience significantly greater perceptions of fear and more intense fear (P
Original languageEnglish
Pages (from-to)114-22
Number of pages9
Issue number1
Publication statusPublished - Jan 2014

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