The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage

Aram O. Saeed; Ben Newland; Abhay Pandit; Wenxin Wang

doi:10.1039/c1cc16538k

The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage

Aram O. Saeed, Ben Newland, Abhay Pandit, Wenxin Wang

Pharmaceutical Materials and Soft Matter

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

In contrast to the usual inclusion of disulfide bonds within a polymer structure to facilitate bio-degradation, we have designed a self-curing “one pot” hyperbranched polymer capable of forming crosslinked gels under reducing conditions abundant in tumoural tissue.

Original language	English
Pages (from-to)	585-587
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	4
DOIs	https://doi.org/10.1039/c1cc16538k
Publication status	Published - 1 Jan 2012

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10.1039/c1cc16538k

Cite this

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title = "The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage",

abstract = "In contrast to the usual inclusion of disulfide bonds within a polymer structure to facilitate bio-degradation, we have designed a self-curing “one pot” hyperbranched polymer capable of forming crosslinked gels under reducing conditions abundant in tumoural tissue.",

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N2 - In contrast to the usual inclusion of disulfide bonds within a polymer structure to facilitate bio-degradation, we have designed a self-curing “one pot” hyperbranched polymer capable of forming crosslinked gels under reducing conditions abundant in tumoural tissue.

AB - In contrast to the usual inclusion of disulfide bonds within a polymer structure to facilitate bio-degradation, we have designed a self-curing “one pot” hyperbranched polymer capable of forming crosslinked gels under reducing conditions abundant in tumoural tissue.

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DO - 10.1039/c1cc16538k

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EP - 587

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JF - Chemical Communications

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