The role of biologics in treatment of ANCA-associated vasculitis

Chethana Dharmapalaiah, Richard A. Watts

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The vast majority of patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV) who receive conventional treatment with glucocorticoids and cyclophosphamide experience frequent relapses and treatment-related side-effects. Increasing knowledge of the pathogenesis of AAV has permitted the development of targeted therapies against tumour necrosis factor (TNF)-a and T and B lymphocytes. Therapy with TNF-a blocking drugs has so far proved disappointing, and this approach is not recommended. B cell depletion using rituximab is effective for remission induction, especially in refractory patients. The long-term side-effects and the best method of using rituximab to maintain remission are still to be determined.
Original languageEnglish
Pages (from-to)319-326
JournalModern Rheumatology
Volume22
Issue number3
Early online date29 Oct 2011
DOIs
Publication statusPublished - Jun 2012

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