The role of diet in the aetiopathogenesis of inflammatory bowel disease

Hamed Khalili, Simon Chan, Paul Lochhead, Ashwin N. Ananthakrishnan, Andrew Hart, Andrew T. Chan

Research output: Contribution to journalReview articlepeer-review

167 Citations (Scopus)
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Crohn’s disease and ulcerative colitis, collectively known as IBD, are chronic inflammatory disorders of the gastrointestinal tract. Although the aetiopathogenesis of IBD is largely unknown, it is widely thought that diet has a crucial role in the development and progression of IBD. Indeed, epidemiological and genetic association studies have identified a number of promising dietary and genetic risk factors for IBD. These preliminary studies have led to major interest in investigating the complex interaction between diet, host genetics, the gut microbiota and immune function in the pathogenesis of IBD. In this Review, we discuss the recent epidemiological, gene–environment interaction, microbiome and animal studies that have explored the relationship between diet and the risk of IBD. In addition, we highlight the limitations of these prior studies, in part by explaining their contradictory findings, and review future directions.
Original languageEnglish
JournalNature Reviews: Gastroenterology and Hepatology
Early online date22 May 2018
Publication statusPublished - Sep 2018

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