The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise

Jonathan P. R. Scott, Craig Sale, Julie P. Greeves, Anna Casey, John Dutton, William D. Fraser

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94 Citations (Scopus)


We compared the effects of exercise intensity (EI) on bone metabolism during and for 4 days after acute, weight-bearing endurance exercise. Ten males [mean ± SD maximum oxygen uptake (Vo(2max)): 56.2 ± 8.1 ml·min(-1)·kg(-1)] completed three counterbalanced 8-day trials. Following three control days, on day 4, subjects completed 60 min of running at 55%, 65%, and 75% Vo(2max). Markers of bone resorption [COOH-terminal telopeptide region of collagen type 1 (β-CTX)] and formation [NH(2)-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone-alkaline phosphatase (ALP)], osteoprotegerin (OPG), parathyroid hormone (PTH), albumin-adjusted calcium (ACa), phosphate (PO(4)), and cortisol were measured during and for 3 h after exercise and on four follow-up days (FU1-FU4). At 75% Vo(2max), β-CTX was not significantly increased from baseline by exercise but was higher compared with 55% (17-19%, P
Original languageEnglish
Pages (from-to)423-432
Number of pages10
JournalJournal of Applied Physiology
Issue number2
Publication statusPublished - Feb 2011


  • Bone Remodeling
  • Bone and Bones
  • Humans
  • Male
  • Physical Endurance
  • Physical Exertion
  • Resistance Training
  • Weight-Bearing
  • Young Adult

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