The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise

Jonathan P. R. Scott; Craig Sale; Julie P. Greeves; Anna Casey; John Dutton; William D. Fraser

doi:10.1152/japplphysiol.00764.2010

The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise

Jonathan P. R. Scott, Craig Sale, Julie P. Greeves, Anna Casey, John Dutton, William D. Fraser

Research output: Contribution to journal › Article › peer-review

97 Citations (Scopus)

Abstract

We compared the effects of exercise intensity (EI) on bone metabolism during and for 4 days after acute, weight-bearing endurance exercise. Ten males [mean ± SD maximum oxygen uptake (Vo(2max)): 56.2 ± 8.1 ml·min(-1)·kg(-1)] completed three counterbalanced 8-day trials. Following three control days, on day 4, subjects completed 60 min of running at 55%, 65%, and 75% Vo(2max). Markers of bone resorption [COOH-terminal telopeptide region of collagen type 1 (β-CTX)] and formation [NH(2)-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone-alkaline phosphatase (ALP)], osteoprotegerin (OPG), parathyroid hormone (PTH), albumin-adjusted calcium (ACa), phosphate (PO(4)), and cortisol were measured during and for 3 h after exercise and on four follow-up days (FU1-FU4). At 75% Vo(2max), β-CTX was not significantly increased from baseline by exercise but was higher compared with 55% (17-19%, P

Original language	English
Pages (from-to)	423-432
Number of pages	10
Journal	Journal of Applied Physiology
Volume	110
Issue number	2
DOIs	https://doi.org/10.1152/japplphysiol.00764.2010
Publication status	Published - Feb 2011

Keywords

Bone Remodeling
Bone and Bones
Humans
Male
Physical Endurance
Physical Exertion
Resistance Training
Weight-Bearing
Young Adult

Access to Document

10.1152/japplphysiol.00764.2010

Cite this

@article{b2278612e4a94d56b65c41150f2cbb72,

title = "The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise",

abstract = "We compared the effects of exercise intensity (EI) on bone metabolism during and for 4 days after acute, weight-bearing endurance exercise. Ten males [mean ± SD maximum oxygen uptake (Vo(2max)): 56.2 ± 8.1 ml·min(-1)·kg(-1)] completed three counterbalanced 8-day trials. Following three control days, on day 4, subjects completed 60 min of running at 55%, 65%, and 75% Vo(2max). Markers of bone resorption [COOH-terminal telopeptide region of collagen type 1 (β-CTX)] and formation [NH(2)-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone-alkaline phosphatase (ALP)], osteoprotegerin (OPG), parathyroid hormone (PTH), albumin-adjusted calcium (ACa), phosphate (PO(4)), and cortisol were measured during and for 3 h after exercise and on four follow-up days (FU1-FU4). At 75% Vo(2max), β-CTX was not significantly increased from baseline by exercise but was higher compared with 55% (17-19%, P ",

keywords = "Bone Remodeling, Bone and Bones, Humans, Male, Physical Endurance, Physical Exertion, Resistance Training, Weight-Bearing, Young Adult",

author = "Scott, {Jonathan P. R.} and Craig Sale and Greeves, {Julie P.} and Anna Casey and John Dutton and Fraser, {William D.}",

year = "2011",

month = feb,

doi = "10.1152/japplphysiol.00764.2010",

language = "English",

volume = "110",

pages = "423--432",

journal = "Journal of Applied Physiology",

issn = "8750-7587",

publisher = "American Physiological Society",

number = "2",

}

TY - JOUR

T1 - The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise

AU - Scott, Jonathan P. R.

AU - Sale, Craig

AU - Greeves, Julie P.

AU - Casey, Anna

AU - Dutton, John

AU - Fraser, William D.

PY - 2011/2

Y1 - 2011/2

N2 - We compared the effects of exercise intensity (EI) on bone metabolism during and for 4 days after acute, weight-bearing endurance exercise. Ten males [mean ± SD maximum oxygen uptake (Vo(2max)): 56.2 ± 8.1 ml·min(-1)·kg(-1)] completed three counterbalanced 8-day trials. Following three control days, on day 4, subjects completed 60 min of running at 55%, 65%, and 75% Vo(2max). Markers of bone resorption [COOH-terminal telopeptide region of collagen type 1 (β-CTX)] and formation [NH(2)-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone-alkaline phosphatase (ALP)], osteoprotegerin (OPG), parathyroid hormone (PTH), albumin-adjusted calcium (ACa), phosphate (PO(4)), and cortisol were measured during and for 3 h after exercise and on four follow-up days (FU1-FU4). At 75% Vo(2max), β-CTX was not significantly increased from baseline by exercise but was higher compared with 55% (17-19%, P

AB - We compared the effects of exercise intensity (EI) on bone metabolism during and for 4 days after acute, weight-bearing endurance exercise. Ten males [mean ± SD maximum oxygen uptake (Vo(2max)): 56.2 ± 8.1 ml·min(-1)·kg(-1)] completed three counterbalanced 8-day trials. Following three control days, on day 4, subjects completed 60 min of running at 55%, 65%, and 75% Vo(2max). Markers of bone resorption [COOH-terminal telopeptide region of collagen type 1 (β-CTX)] and formation [NH(2)-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone-alkaline phosphatase (ALP)], osteoprotegerin (OPG), parathyroid hormone (PTH), albumin-adjusted calcium (ACa), phosphate (PO(4)), and cortisol were measured during and for 3 h after exercise and on four follow-up days (FU1-FU4). At 75% Vo(2max), β-CTX was not significantly increased from baseline by exercise but was higher compared with 55% (17-19%, P

KW - Bone Remodeling

KW - Bone and Bones

KW - Humans

KW - Male

KW - Physical Endurance

KW - Physical Exertion

KW - Resistance Training

KW - Weight-Bearing

KW - Young Adult

U2 - 10.1152/japplphysiol.00764.2010

DO - 10.1152/japplphysiol.00764.2010

M3 - Article

C2 - 21127210

VL - 110

SP - 423

EP - 432

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 2

ER -