The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise

Jonathan P. R. Scott; Craig Sale; Julie P. Greeves; Anna Casey; John Dutton; William D. Fraser

doi:10.1152/japplphysiol.00764.2010

The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise

Jonathan P. R. Scott, Craig Sale, Julie P. Greeves, Anna Casey, John Dutton, William D. Fraser

Research output: Contribution to journal › Article › peer-review

106 Citations (Scopus)

Abstract

We compared the effects of exercise intensity (EI) on bone metabolism during and for 4 days after acute, weight-bearing endurance exercise. Ten males [mean ± SD maximum oxygen uptake (Vo(2max)): 56.2 ± 8.1 ml·min(-1)·kg(-1)] completed three counterbalanced 8-day trials. Following three control days, on day 4, subjects completed 60 min of running at 55%, 65%, and 75% Vo(2max). Markers of bone resorption [COOH-terminal telopeptide region of collagen type 1 (β-CTX)] and formation [NH(2)-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone-alkaline phosphatase (ALP)], osteoprotegerin (OPG), parathyroid hormone (PTH), albumin-adjusted calcium (ACa), phosphate (PO(4)), and cortisol were measured during and for 3 h after exercise and on four follow-up days (FU1-FU4). At 75% Vo(2max), β-CTX was not significantly increased from baseline by exercise but was higher compared with 55% (17-19%, P

Original language	English
Pages (from-to)	423-432
Number of pages	10
Journal	Journal of Applied Physiology
Volume	110
Issue number	2
DOIs	https://doi.org/10.1152/japplphysiol.00764.2010
Publication status	Published - Feb 2011

Keywords

Bone Remodeling
Bone and Bones
Humans
Male
Physical Endurance
Physical Exertion
Resistance Training
Weight-Bearing
Young Adult

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10.1152/japplphysiol.00764.2010

Cite this

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title = "The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise",

abstract = "We compared the effects of exercise intensity (EI) on bone metabolism during and for 4 days after acute, weight-bearing endurance exercise. Ten males [mean ± SD maximum oxygen uptake (Vo(2max)): 56.2 ± 8.1 ml·min(-1)·kg(-1)] completed three counterbalanced 8-day trials. Following three control days, on day 4, subjects completed 60 min of running at 55%, 65%, and 75% Vo(2max). Markers of bone resorption [COOH-terminal telopeptide region of collagen type 1 (β-CTX)] and formation [NH(2)-terminal propeptides of procollagen type 1 (P1NP), osteocalcin (OC), bone-alkaline phosphatase (ALP)], osteoprotegerin (OPG), parathyroid hormone (PTH), albumin-adjusted calcium (ACa), phosphate (PO(4)), and cortisol were measured during and for 3 h after exercise and on four follow-up days (FU1-FU4). At 75% Vo(2max), β-CTX was not significantly increased from baseline by exercise but was higher compared with 55% (17-19%, P ",

keywords = "Bone Remodeling, Bone and Bones, Humans, Male, Physical Endurance, Physical Exertion, Resistance Training, Weight-Bearing, Young Adult",

author = "Scott, {Jonathan P. R.} and Craig Sale and Greeves, {Julie P.} and Anna Casey and John Dutton and Fraser, {William D.}",

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AU - Dutton, John

AU - Fraser, William D.

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