The role of human orbitofrontal cortex in value comparison for incommensurable objects

Thomas H B FitzGerald, Ben Seymour, Raymond J Dolan

Research output: Contribution to journalArticle

204 Citations (Scopus)

Abstract

The human orbitofrontal cortex is strongly implicated in appetitive valuation. Whether its role extends to support comparative valuation necessary to explain probabilistic choice patterns for incommensurable goods is unknown. Using a binary choice paradigm, we derived the subjective values of different bundles of goods, under conditions of both gain and loss. We demonstrate that orbitofrontal activation reflects the difference in subjective value between available options, an effect evident across valuation for both gains and losses. In contrast, activation in dorsal striatum and supplementary motor areas reflects subjects' choice probabilities. These findings indicate that orbitofrontal cortex plays a pivotal role in valuation for incommensurable goods, a critical component process in human decision making.

Original languageEnglish
Pages (from-to)8388-95
Number of pages8
JournalThe Journal of Neuroscience
Volume29
Issue number26
DOIs
Publication statusPublished - 1 Jul 2009

Keywords

  • Adult
  • Analysis of Variance
  • Brain Mapping
  • Cues
  • Decision Making
  • Female
  • Frontal Lobe
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Oxygen
  • Photic Stimulation
  • Probability
  • Reaction Time
  • Reward
  • Task Performance and Analysis
  • Time Factors
  • Young Adult

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