The role of MCM/P1 proteins in the licensing of DNA replication

James P. J. Chong, Pia Thömmes, J. Julian Blow

Research output: Contribution to journalArticlepeer-review


The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.
Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalTrends in Biochemical Sciences
Issue number3
Publication statusPublished - Mar 1996

Cite this