The role of MCM/P1 proteins in the licensing of DNA replication

James P. J. Chong; Pia Thömmes; J. Julian Blow

doi:10.1016/S0968-0004(96)10013-X

The role of MCM/P1 proteins in the licensing of DNA replication

James P. J. Chong, Pia Thömmes, J. Julian Blow

Vice-Chancellor's Office

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159 Citations (Scopus)

Abstract

The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.

Original language	English
Pages (from-to)	102-106
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/S0968-0004(96)10013-X
Publication status	Published - Mar 1996

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10.1016/S0968-0004(96)10013-X

Cite this

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title = "The role of MCM/P1 proteins in the licensing of DNA replication",

abstract = "The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.",

author = "Chong, {James P. J.} and Pia Th{\"o}mmes and Blow, {J. Julian}",

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AB - The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.

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