The role of spalt proteins in development and disease

Dylan Sweetman, Andrea Munsterberg

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)
9 Downloads (Pure)

Abstract

The spalt proteins are encoded by a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans and vertebrates. In humans, mutations in some of these genes are associated with several congenital disorders which underscores the importance of spalt gene function in embryonic development. Recent studies have begun to cast light on the functions of this family of proteins with increasing understanding of the developmental processes regulated and the molecular mechanisms used. Here we review what is currently known about the role of spalt genes in vertebrate development and human disease.
Original languageEnglish
Pages (from-to)285-293
Number of pages9
JournalDevelopmental Biology
Volume293
Issue number2
DOIs
Publication statusPublished - 2006

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