The role of the replication licensing system in cell proliferation and cancer

S. Shreeram, J. Blow

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21 Citations (Scopus)


The precise duplication of chromosomal DNA during each cell cycle is essential for the maintenance of genetic stability. Failure to correctly regulate chromosomal DNA replication could lead to losses or duplication of chromosome segments. The precise duplication of chromosomes is normally achieved by correct regulation of the replication licensing system. Here we review our current knowledge of the licensing system and how this might be defective in cancer cells. We also review how detection of licensing components can be used for the diagnosis and prognosis of cancer. Finally we discuss the potential of the replication licensing system as a novel anti-cancer target.
Original languageEnglish
Pages (from-to)287-293
Number of pages7
JournalProgress in Cell Cycle Research
Publication statusPublished - 2003

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