The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

Paolo Biancheri; Paolo Giuffrida; Guillermo H Docena; Thomas T MacDonald; Gino Roberto Corazza; Antonio Di Sabatino

doi:10.1016/j.cytogfr.2013.11.001

The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

Paolo Biancheri, Paolo Giuffrida, Guillermo H Docena, Thomas T MacDonald, Gino Roberto Corazza, Antonio Di Sabatino

Research output: Contribution to journal › Review article › peer-review

85 Citations (Scopus)

Abstract

Transforming growth factor (TGF)-β, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-β also enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-β signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-β signaling in chronic intestinal diseases.

Original language	English
Pages (from-to)	45-55
Number of pages	11
Journal	Cytokine & Growth Factor Reviews
Volume	25
Issue number	1
Early online date	28 Nov 2013
DOIs	https://doi.org/10.1016/j.cytogfr.2013.11.001
Publication status	Published - Feb 2014

Keywords

Animals
Cell Differentiation/physiology
Humans
Immune Tolerance/drug effects
Inflammatory Bowel Diseases/immunology
Intestinal Mucosa/immunology
Intestines/immunology
Mice
Signal Transduction/physiology
T-Lymphocytes, Regulatory/physiology
Transforming Growth Factor beta/physiology
Wound Healing

Access to Document

10.1016/j.cytogfr.2013.11.001

Cite this

@article{b520293e3cd74457a1441a237c1e153f,

title = "The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut",

abstract = "Transforming growth factor (TGF)-β, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-β also enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-β signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-β signaling in chronic intestinal diseases. ",

keywords = "Animals, Cell Differentiation/physiology, Humans, Immune Tolerance/drug effects, Inflammatory Bowel Diseases/immunology, Intestinal Mucosa/immunology, Intestines/immunology, Mice, Signal Transduction/physiology, T-Lymphocytes, Regulatory/physiology, Transforming Growth Factor beta/physiology, Wound Healing",

author = "Paolo Biancheri and Paolo Giuffrida and Docena, {Guillermo H} and MacDonald, {Thomas T} and Corazza, {Gino Roberto} and {Di Sabatino}, Antonio",

year = "2014",

month = feb,

doi = "10.1016/j.cytogfr.2013.11.001",

language = "English",

volume = "25",

pages = "45--55",

journal = "Cytokine & Growth Factor Reviews",

issn = "1359-6101",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

AU - Biancheri, Paolo

AU - Giuffrida, Paolo

AU - Docena, Guillermo H

AU - MacDonald, Thomas T

AU - Corazza, Gino Roberto

AU - Di Sabatino, Antonio

PY - 2014/2

Y1 - 2014/2

N2 - Transforming growth factor (TGF)-β, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-β also enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-β signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-β signaling in chronic intestinal diseases.

AB - Transforming growth factor (TGF)-β, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-β also enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-β signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-β signaling in chronic intestinal diseases.

KW - Animals

KW - Cell Differentiation/physiology

KW - Humans

KW - Immune Tolerance/drug effects

KW - Inflammatory Bowel Diseases/immunology

KW - Intestinal Mucosa/immunology

KW - Intestines/immunology

KW - Mice

KW - Signal Transduction/physiology

KW - T-Lymphocytes, Regulatory/physiology

KW - Transforming Growth Factor beta/physiology

KW - Wound Healing

U2 - 10.1016/j.cytogfr.2013.11.001

DO - 10.1016/j.cytogfr.2013.11.001

M3 - Review article

C2 - 24332927

SN - 1359-6101

VL - 25

SP - 45

EP - 55

JO - Cytokine & Growth Factor Reviews

JF - Cytokine & Growth Factor Reviews

IS - 1

ER -