The role of vascular myoglobin in nitrite-mediated blood vessel relaxation

Julian O M Ormerod, Houman Ashrafian, Abdul R Maher, Sayqa Arif, Violetta Steeples, Gustav V R Born, Stuart Egginton, Martin Feelisch, Hugh Watkins, Michael P Frenneaux

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

This work investigates the role of myoglobin in mediating the vascular relaxation induced by nitrite. Nitrite, previously considered an inert by-product of nitric oxide metabolism, is now believed to play an important role in several areas of pharmacology and physiology. Myoglobin can act as a nitrite reductase in the heart, where it is plentiful, but it is present at a far lower level in vascular smooth muscle-indeed, its existence in the vessel wall is controversial. Haem proteins have been postulated to be important in nitrite-induced vasodilation, but the specific role of myoglobin is unknown. The current study was designed to confirm the presence of myoglobin in murine aortic tissue and to test the hypothesis that vascular wall myoglobin is important for nitrite-induced vasodilation.
Original languageEnglish
Pages (from-to)560-5
Number of pages6
JournalCardiovascular Research
Volume89
Issue number3
DOIs
Publication statusPublished - 15 Feb 2011

Keywords

  • Animals
  • Aorta
  • Carbon Monoxide
  • Drug Interactions
  • Male
  • Mice
  • Mice, Knockout
  • Muscle, Smooth, Vascular
  • Myoglobin
  • Nitric Oxide
  • Nitric Oxide Donors
  • Nitrite Reductases
  • Nitrites
  • Nitroprusside
  • Vasodilation

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