The roles of tissue inhibitors of metalloproteinases in tissue remodelling and cell growth

D R Edwards; P P Beaudry; T D Laing; V Kowal; K J Leco; P A Leco; M S Lim

The roles of tissue inhibitors of metalloproteinases in tissue remodelling and cell growth

D R Edwards, P P Beaudry, T D Laing, V Kowal, K J Leco, P A Leco, M S Lim

Research output: Contribution to journal › Article › peer-review

141 Citations (Scopus)

Abstract

Tissue inhibitors of metalloproteinases (TIMPs) are secreted proteins that block the activities of the extracellular matrix (ECM)-degrading metalloproteinases (MMPs). As key determinants of ECM integrity and turnover, TIMPs are involved in the establishment and maintenance of tissue architecture and may indirectly influence ECM-dependent cells signaling. In addition, TIMPs exert both positive and negative effects on cell growth through mechanisms that are independent of MMP inhibition. The three members of the mammalian TIMP family differ in structure, biochemical properties and expression, suggesting that they have distinct physiological roles. Here, we review recent advances in our understanding of TIMP protein function and gene regulation. We discuss the potential relevance of MMPs and TIMPs in obesity with regard to effects on the processing of tumor necrosis factor-alpha.

Original language	English
Pages (from-to)	S9-15
Journal	International Journal of Obesity
Volume	20
Issue number	Suppl 3
Publication status	Published - Mar 1996

Keywords

Animals
Cell Division
Extracellular Matrix
Gene Expression Regulation
Glycoproteins
Humans
Metalloendopeptidases
Signal Transduction
Tissue Inhibitor of Metalloproteinases

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Cite this

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title = "The roles of tissue inhibitors of metalloproteinases in tissue remodelling and cell growth",

abstract = "Tissue inhibitors of metalloproteinases (TIMPs) are secreted proteins that block the activities of the extracellular matrix (ECM)-degrading metalloproteinases (MMPs). As key determinants of ECM integrity and turnover, TIMPs are involved in the establishment and maintenance of tissue architecture and may indirectly influence ECM-dependent cells signaling. In addition, TIMPs exert both positive and negative effects on cell growth through mechanisms that are independent of MMP inhibition. The three members of the mammalian TIMP family differ in structure, biochemical properties and expression, suggesting that they have distinct physiological roles. Here, we review recent advances in our understanding of TIMP protein function and gene regulation. We discuss the potential relevance of MMPs and TIMPs in obesity with regard to effects on the processing of tumor necrosis factor-alpha.",

keywords = "Animals, Cell Division, Extracellular Matrix, Gene Expression Regulation, Glycoproteins, Humans, Metalloendopeptidases, Signal Transduction, Tissue Inhibitor of Metalloproteinases",

author = "Edwards, {D R} and Beaudry, {P P} and Laing, {T D} and V Kowal and Leco, {K J} and Leco, {P A} and Lim, {M S}",

year = "1996",

month = mar,

language = "English",

volume = "20",

pages = "S9--15",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "Nature Publishing Group",

number = "Suppl 3",

}

TY - JOUR

T1 - The roles of tissue inhibitors of metalloproteinases in tissue remodelling and cell growth

AU - Edwards, D R

AU - Beaudry, P P

AU - Laing, T D

AU - Kowal, V

AU - Leco, K J

AU - Leco, P A

AU - Lim, M S

PY - 1996/3

Y1 - 1996/3

N2 - Tissue inhibitors of metalloproteinases (TIMPs) are secreted proteins that block the activities of the extracellular matrix (ECM)-degrading metalloproteinases (MMPs). As key determinants of ECM integrity and turnover, TIMPs are involved in the establishment and maintenance of tissue architecture and may indirectly influence ECM-dependent cells signaling. In addition, TIMPs exert both positive and negative effects on cell growth through mechanisms that are independent of MMP inhibition. The three members of the mammalian TIMP family differ in structure, biochemical properties and expression, suggesting that they have distinct physiological roles. Here, we review recent advances in our understanding of TIMP protein function and gene regulation. We discuss the potential relevance of MMPs and TIMPs in obesity with regard to effects on the processing of tumor necrosis factor-alpha.

AB - Tissue inhibitors of metalloproteinases (TIMPs) are secreted proteins that block the activities of the extracellular matrix (ECM)-degrading metalloproteinases (MMPs). As key determinants of ECM integrity and turnover, TIMPs are involved in the establishment and maintenance of tissue architecture and may indirectly influence ECM-dependent cells signaling. In addition, TIMPs exert both positive and negative effects on cell growth through mechanisms that are independent of MMP inhibition. The three members of the mammalian TIMP family differ in structure, biochemical properties and expression, suggesting that they have distinct physiological roles. Here, we review recent advances in our understanding of TIMP protein function and gene regulation. We discuss the potential relevance of MMPs and TIMPs in obesity with regard to effects on the processing of tumor necrosis factor-alpha.

KW - Animals

KW - Cell Division

KW - Extracellular Matrix

KW - Gene Expression Regulation

KW - Glycoproteins

KW - Humans

KW - Metalloendopeptidases

KW - Signal Transduction

KW - Tissue Inhibitor of Metalloproteinases

M3 - Article

C2 - 8680484

VL - 20

SP - S9-15

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - Suppl 3

ER -