The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine

Hayley C. Whitaker; Zsofia Kote-Jarai; Helen Ross-Adams; Anne Y. Warren; Johanna Burge; Anne George; Elizabeth Bancroft; Sameer Jhavar; Daniel Leongamornlert; Malgorzata Tymrakiewicz; Edward Saunders; Elizabeth Page; Anita Mitra; Gillian Mitchell; Geoffrey J. Lindeman; D. Gareth Evans; Ignacio Blanco; Catherine Mercer; Wendy S. Rubinstein; Virginia Clowes; Fiona Douglas; Shirley Hodgson; Lisa Walker; Alan Donaldson; Louise Izatt; Huw Dorkins; Alison Male; Kathy Tucker; Alan Stapleton; Jimmy Lam; Judy Kirk; Hans Lilja; Douglas Easton; IMPACT Study Steering Committee; IMPACT Study Collaborators; UK GPCS Collaborators; Colin Cooper; Rosalind Eeles; David E. Neal

doi:10.1371/journal.pone.0013363

The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine

Hayley C. Whitaker, Zsofia Kote-Jarai, Helen Ross-Adams, Anne Y. Warren, Johanna Burge, Anne George, Elizabeth Bancroft, Sameer Jhavar, Daniel Leongamornlert, Malgorzata Tymrakiewicz, Edward Saunders, Elizabeth Page, Anita Mitra, Gillian Mitchell, Geoffrey J. Lindeman, D. Gareth Evans, Ignacio Blanco, Catherine Mercer, Wendy S. Rubinstein, Virginia ClowesFiona Douglas, Shirley Hodgson, Lisa Walker, Alan Donaldson, Louise Izatt, Huw Dorkins, Alison Male, Kathy Tucker, Alan Stapleton, Jimmy Lam, Judy Kirk, Hans Lilja, Douglas Easton, IMPACT Study Steering Committee, IMPACT Study Collaborators, UK GPCS Collaborators, Colin Cooper, Rosalind Eeles, David E. Neal

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in benign tissue leading to increased prostate cancer risk.

Original language	English
Article number	e13363
Journal	PLoS One
Volume	5
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0013363
Publication status	Published - 13 Oct 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alleles
Enzyme-Linked Immunosorbent Assay
Genetic Predisposition to Disease
Genotype
Humans
Immunohistochemistry
Male
Prostate-Specific Antigen
Prostatic Neoplasms
Prostatic Secretory Proteins
Tumor Markers, Biological

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10.1371/journal.pone.0013363Licence: CC BY

Cite this

Whitaker, H. C., Kote-Jarai, Z., Ross-Adams, H., Warren, A. Y., Burge, J., George, A., Bancroft, E., Jhavar, S., Leongamornlert, D., Tymrakiewicz, M., Saunders, E., Page, E., Mitra, A., Mitchell, G., Lindeman, G. J., Evans, D. G., Blanco, I., Mercer, C., Rubinstein, W. S., ... Neal, D. E. (2010). The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine. PLoS One, 5(10), Article e13363. https://doi.org/10.1371/journal.pone.0013363

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title = "The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine",

abstract = "Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in benign tissue leading to increased prostate cancer risk.",

keywords = "Alleles, Enzyme-Linked Immunosorbent Assay, Genetic Predisposition to Disease, Genotype, Humans, Immunohistochemistry, Male, Prostate-Specific Antigen, Prostatic Neoplasms, Prostatic Secretory Proteins, Tumor Markers, Biological",

author = "Whitaker, {Hayley C.} and Zsofia Kote-Jarai and Helen Ross-Adams and Warren, {Anne Y.} and Johanna Burge and Anne George and Elizabeth Bancroft and Sameer Jhavar and Daniel Leongamornlert and Malgorzata Tymrakiewicz and Edward Saunders and Elizabeth Page and Anita Mitra and Gillian Mitchell and Lindeman, {Geoffrey J.} and Evans, {D. Gareth} and Ignacio Blanco and Catherine Mercer and Rubinstein, {Wendy S.} and Virginia Clowes and Fiona Douglas and Shirley Hodgson and Lisa Walker and Alan Donaldson and Louise Izatt and Huw Dorkins and Alison Male and Kathy Tucker and Alan Stapleton and Jimmy Lam and Judy Kirk and Hans Lilja and Douglas Easton and {IMPACT Study Steering Committee} and {IMPACT Study Collaborators} and {UK GPCS Collaborators} and Colin Cooper and Rosalind Eeles and Neal, {David E.}",

year = "2010",

month = oct,

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doi = "10.1371/journal.pone.0013363",

language = "English",

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Whitaker, HC, Kote-Jarai, Z, Ross-Adams, H, Warren, AY, Burge, J, George, A, Bancroft, E, Jhavar, S, Leongamornlert, D, Tymrakiewicz, M, Saunders, E, Page, E, Mitra, A, Mitchell, G, Lindeman, GJ, Evans, DG, Blanco, I, Mercer, C, Rubinstein, WS, Clowes, V, Douglas, F, Hodgson, S, Walker, L, Donaldson, A, Izatt, L, Dorkins, H, Male, A, Tucker, K, Stapleton, A, Lam, J, Kirk, J, Lilja, H, Easton, D, IMPACT Study Steering Committee, IMPACT Study Collaborators, UK GPCS Collaborators, Cooper, C, Eeles, R & Neal, DE 2010, 'The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine', PLoS One, vol. 5, no. 10, e13363. https://doi.org/10.1371/journal.pone.0013363

TY - JOUR

T1 - The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine

AU - Whitaker, Hayley C.

AU - Kote-Jarai, Zsofia

AU - Ross-Adams, Helen

AU - Warren, Anne Y.

AU - Burge, Johanna

AU - George, Anne

AU - Bancroft, Elizabeth

AU - Jhavar, Sameer

AU - Leongamornlert, Daniel

AU - Tymrakiewicz, Malgorzata

AU - Saunders, Edward

AU - Page, Elizabeth

AU - Mitra, Anita

AU - Mitchell, Gillian

AU - Lindeman, Geoffrey J.

AU - Evans, D. Gareth

AU - Blanco, Ignacio

AU - Mercer, Catherine

AU - Rubinstein, Wendy S.

AU - Clowes, Virginia

AU - Douglas, Fiona

AU - Hodgson, Shirley

AU - Walker, Lisa

AU - Donaldson, Alan

AU - Izatt, Louise

AU - Dorkins, Huw

AU - Male, Alison

AU - Tucker, Kathy

AU - Stapleton, Alan

AU - Lam, Jimmy

AU - Kirk, Judy

AU - Lilja, Hans

AU - Easton, Douglas

AU - IMPACT Study Steering Committee

AU - IMPACT Study Collaborators

AU - UK GPCS Collaborators

AU - Cooper, Colin

AU - Eeles, Rosalind

AU - Neal, David E.

PY - 2010/10/13

Y1 - 2010/10/13

N2 - Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in benign tissue leading to increased prostate cancer risk.

AB - Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in benign tissue leading to increased prostate cancer risk.

KW - Alleles

KW - Enzyme-Linked Immunosorbent Assay

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Prostate-Specific Antigen

KW - Prostatic Neoplasms

KW - Prostatic Secretory Proteins

KW - Tumor Markers, Biological

U2 - 10.1371/journal.pone.0013363

DO - 10.1371/journal.pone.0013363

M3 - Article

C2 - 20967219

SN - 1932-6203

VL - 5

JO - PLoS One

JF - PLoS One

IS - 10

M1 - e13363

ER -