The phytochemical analysis of two collections of a new species (SAC-2825), tentatively assigned as aff. Samadera bidwillii (Simaroubaceae), has yielded a limonoid (limonin), a quassinoid (2′-acetoxyglaucarubin), three alkaloids [2-(10′ξ-acetoxyundecanyl)-1-acetoxymethyl-4-quinolone, 1-methoxy-10-methyl-acridan-9-one and 1,8-dihydroxyacridan-9-one] and seven bicyclo-octane type lignans [(−)-sesamin, (−)-episesamin, fargesin, neofargesin, (−)-kobusin, (−)-epieudesmin and (−)-eudesmin]. The 4-quinolone alkaloid appears to be novel. The metabolites identified are collectively typical of the Rutales, but have a biosynthetic range never previously found together in a single species. Particularly noteworthy is the co-occurrence of limonoids and quassinoids in the same plant, which is currently unique to SAC-2825.