The solution conformation of glycosyl inositols related to inositolphosphoglycan (IPG) mediators

M Martin-Lomas; P.M Nieto; N Khiar; S Garcı́a; M Flores-Mosquera; E Poirot; J Angulo; J.l Muñoz

doi:10.1016/S0957-4166(99)00588-1

The solution conformation of glycosyl inositols related to inositolphosphoglycan (IPG) mediators

M Martin-Lomas, P.M Nieto, N Khiar, S Garcı́a, M Flores-Mosquera, E Poirot, J Angulo, J.l Muñoz

Pharmaceutical Materials and Soft Matter

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The preferred solution conformation of the pseudodisaccharides 7–15, containing the structural motifs that have been proposed for the putative inositolphosphoglycan (IPG) mediators of intracellular signalling processes, have been investigated using NMR spectroscopy and molecular mechanics calculations. The results indicate that the different structural motifs (a and ß 1–6 or a and ß 1–4 glucosaminyl-d-myo-inositol; a and ß 1–6 glucosaminyl-d-chiro-inositol) adopt various three-dimensional shapes that may modulate their biological properties.

Original language	English
Pages (from-to)	37-51
Number of pages	15
Journal	Tetrahedron: Asymmetry
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/S0957-4166(99)00588-1
Publication status	Published - 28 Jan 2000

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10.1016/S0957-4166(99)00588-1

Cite this

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title = "The solution conformation of glycosyl inositols related to inositolphosphoglycan (IPG) mediators",

abstract = "The preferred solution conformation of the pseudodisaccharides 7–15, containing the structural motifs that have been proposed for the putative inositolphosphoglycan (IPG) mediators of intracellular signalling processes, have been investigated using NMR spectroscopy and molecular mechanics calculations. The results indicate that the different structural motifs (a and {\ss} 1–6 or a and {\ss} 1–4 glucosaminyl-d-myo-inositol; a and {\ss} 1–6 glucosaminyl-d-chiro-inositol) adopt various three-dimensional shapes that may modulate their biological properties.",

author = "M Martin-Lomas and P.M Nieto and N Khiar and S Garc{\'ı}a and M Flores-Mosquera and E Poirot and J Angulo and J.l Mu{\~n}oz",

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AU - Martin-Lomas, M

AU - Nieto, P.M

AU - Khiar, N

AU - Garcı́a, S

AU - Flores-Mosquera, M

AU - Poirot, E

AU - Angulo, J

AU - Muñoz, J.l

PY - 2000/1/28

Y1 - 2000/1/28

N2 - The preferred solution conformation of the pseudodisaccharides 7–15, containing the structural motifs that have been proposed for the putative inositolphosphoglycan (IPG) mediators of intracellular signalling processes, have been investigated using NMR spectroscopy and molecular mechanics calculations. The results indicate that the different structural motifs (a and ß 1–6 or a and ß 1–4 glucosaminyl-d-myo-inositol; a and ß 1–6 glucosaminyl-d-chiro-inositol) adopt various three-dimensional shapes that may modulate their biological properties.

AB - The preferred solution conformation of the pseudodisaccharides 7–15, containing the structural motifs that have been proposed for the putative inositolphosphoglycan (IPG) mediators of intracellular signalling processes, have been investigated using NMR spectroscopy and molecular mechanics calculations. The results indicate that the different structural motifs (a and ß 1–6 or a and ß 1–4 glucosaminyl-d-myo-inositol; a and ß 1–6 glucosaminyl-d-chiro-inositol) adopt various three-dimensional shapes that may modulate their biological properties.

U2 - 10.1016/S0957-4166(99)00588-1

DO - 10.1016/S0957-4166(99)00588-1

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