The Third Hydrogenase: A Ferracyclic Carbamoyl with Close Structural Analogy to the Active Site of Hmd

Peter J. Turrell, Joseph A. Wright, Jamie N. T. Peck, Vasily S. Oganesyan, Christopher J. Pickett

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Abstract

The synthesis of a close structural analogue of the active site of [Fe]-hydrogenase is described (see structure; C gray, H dark blue, Fe green, N light blue, O red, S yellow). Nature most probably constructs the five membered ferracyclic ring to poise the 2-hydroxy pyridine substituent in a position to assist the heterolytic cleavage of dihydrogen, and the accessibility of the analogue should now provide opportunities for probing this.
Original languageEnglish
Pages (from-to)7508-7511
Number of pages4
JournalAngewandte Chemie International Edition
Volume49
Issue number41
DOIs
Publication statusPublished - 25 Aug 2010

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