TY - JOUR
T1 - The tomato receptor CuRe1 senses a cell wall protein to identify Cuscuta as a pathogen
AU - Hegenauer, Volker
AU - Slaby, Peter
AU - Körner, Max
AU - Bruckmüller, Julien Alexander
AU - Burggraf, Ronja
AU - Albert, Isabell
AU - Kaiser, Bettina
AU - Löffelhardt, Birgit
AU - Droste-Borel, Irina
AU - Sklenar, Jan
AU - Menke, Frank L.H.
AU - Maček, Boris
AU - Ranjan, Aashish
AU - Sinha, Neelima
AU - Nürnberger, Thorsten
AU - Felix, Georg
AU - Krause, Kirsten
AU - Stahl, Mark
AU - Albert, Markus
PY - 2020/10/20
Y1 - 2020/10/20
N2 - Parasitic plants of the genus Cuscuta penetrate shoots of host plants with haustoria and build a connection to the host vasculature to exhaust water, solutes and carbohydrates. Such infections usually stay unrecognized by the host and lead to harmful host plant damage. Here, we show a molecular mechanism of how plants can sense parasitic Cuscuta. We isolated an 11 kDa protein of the parasite cell wall and identified it as a glycine-rich protein (GRP). This GRP, as well as its minimal peptide epitope Crip21, serve as a pathogen-associated molecular pattern and specifically bind and activate a membrane-bound immune receptor of tomato, the Cuscuta Receptor 1 (CuRe1), leading to defense responses in resistant hosts. These findings provide the initial steps to understand the resistance mechanisms against parasitic plants and further offer great potential for protecting crops by engineering resistance against parasitic plants.
AB - Parasitic plants of the genus Cuscuta penetrate shoots of host plants with haustoria and build a connection to the host vasculature to exhaust water, solutes and carbohydrates. Such infections usually stay unrecognized by the host and lead to harmful host plant damage. Here, we show a molecular mechanism of how plants can sense parasitic Cuscuta. We isolated an 11 kDa protein of the parasite cell wall and identified it as a glycine-rich protein (GRP). This GRP, as well as its minimal peptide epitope Crip21, serve as a pathogen-associated molecular pattern and specifically bind and activate a membrane-bound immune receptor of tomato, the Cuscuta Receptor 1 (CuRe1), leading to defense responses in resistant hosts. These findings provide the initial steps to understand the resistance mechanisms against parasitic plants and further offer great potential for protecting crops by engineering resistance against parasitic plants.
UR - http://www.scopus.com/inward/record.url?scp=85092890530&partnerID=8YFLogxK
U2 - 10.1038/s41467-020-19147-4
DO - 10.1038/s41467-020-19147-4
M3 - Article
AN - SCOPUS:85092890530
SN - 2041-1723
VL - 11
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5299
ER -