The Use of Co-crystals for the Determination of Absolute Stereochemistry: An Alternative to Salt Formation

Kevin S. Eccles, Rebecca E. Deasy, Laszlo Fabian, Anita R. Maguire, Simon E. Lawrence

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.
Original languageEnglish
Pages (from-to)1159-1162
Number of pages4
JournalThe Journal of Organic Chemistry
Volume76
Issue number4
DOIs
Publication statusPublished - 2011

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