The use of co-crystals for the determination of absolute stereochemistry: An alternative to salt formation

Kevin S. Eccles; Rebecca E. Deasy; Laszlo Fabian; Anita R. Maguire; Simon E. Lawrence

doi:10.1021/jo102148p

The use of co-crystals for the determination of absolute stereochemistry: An alternative to salt formation

Kevin S. Eccles, Rebecca E. Deasy, Laszlo Fabian, Anita R. Maguire, Simon E. Lawrence

Pharmaceutical Materials and Soft Matter

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.

Original language	English
Pages (from-to)	1159-1162
Number of pages	4
Journal	The Journal of Organic Chemistry
Volume	76
Issue number	4
DOIs	https://doi.org/10.1021/jo102148p
Publication status	Published - 2011

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10.1021/jo102148p

Cite this

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title = "The use of co-crystals for the determination of absolute stereochemistry: An alternative to salt formation",

abstract = "Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.",

author = "Eccles, {Kevin S.} and Deasy, {Rebecca E.} and Laszlo Fabian and Maguire, {Anita R.} and Lawrence, {Simon E.}",

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T1 - The use of co-crystals for the determination of absolute stereochemistry: An alternative to salt formation

AU - Eccles, Kevin S.

AU - Deasy, Rebecca E.

AU - Fabian, Laszlo

AU - Maguire, Anita R.

AU - Lawrence, Simon E.

PY - 2011

Y1 - 2011

N2 - Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.

AB - Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.

U2 - 10.1021/jo102148p

DO - 10.1021/jo102148p

M3 - Article

VL - 76

SP - 1159

EP - 1162

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

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