Thiol redox and pKa properties of mycothiol, the predomiant low molecular weight thiol cofactor in the Actinomycetes

Sunil V Sharma; Koen Van Laer; Joris Messens; Chris James Hamilton

doi:10.1002/cbic.201600228

Thiol redox and pKa properties of mycothiol, the predomiant low molecular weight thiol cofactor in the Actinomycetes

Sunil V Sharma, Koen Van Laer, Joris Messens, Chris James Hamilton (Lead Author)

Research output: Contribution to journal › Letter › peer-review

23 Citations (Scopus)

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Abstract

Herein, the thiol pKa and standard redox potential of mycothiol, the major low molecular weight thiol cofactor in the actinomycetes, are reported. The measured standard redox potential reveals substantial discrepancies in one or more of the other previously measured intracellular parameters that are relevant to mycothiol redox biochemistry.

Original language	English
Pages (from-to)	1689–1692
Journal	ChemBioChem
Volume	17
Issue number	18
Early online date	22 Jun 2016
DOIs	https://doi.org/10.1002/cbic.201600228
Publication status	Published - 15 Sep 2016

Keywords

Mycothiol
redox potential
thiol pKa

Access to Document

10.1002/cbic.201600228

ManuscriptAccepted author manuscript, 1.42 MB

Embargoed Document

MSH pKa redox chemBiochem supp info accepted
Accepted author manuscript, 669 KB
Embargo ends: 31/12/99

Methods for Analysing "Invisible" Cellular Disulfides
Hamilton, C.
Leverhulme Trust
1/06/12 → 31/05/14
Project: Research

Cite this

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title = "Thiol redox and pKa properties of mycothiol, the predomiant low molecular weight thiol cofactor in the Actinomycetes",

abstract = "Herein, the thiol pKa and standard redox potential of mycothiol, the major low molecular weight thiol cofactor in the actinomycetes, are reported. The measured standard redox potential reveals substantial discrepancies in one or more of the other previously measured intracellular parameters that are relevant to mycothiol redox biochemistry.",

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AU - Sharma, Sunil V

AU - Van Laer, Koen

AU - Messens, Joris

AU - Hamilton, Chris James

PY - 2016/9/15

Y1 - 2016/9/15

N2 - Herein, the thiol pKa and standard redox potential of mycothiol, the major low molecular weight thiol cofactor in the actinomycetes, are reported. The measured standard redox potential reveals substantial discrepancies in one or more of the other previously measured intracellular parameters that are relevant to mycothiol redox biochemistry.

AB - Herein, the thiol pKa and standard redox potential of mycothiol, the major low molecular weight thiol cofactor in the actinomycetes, are reported. The measured standard redox potential reveals substantial discrepancies in one or more of the other previously measured intracellular parameters that are relevant to mycothiol redox biochemistry.

KW - Mycothiol

KW - redox potential

KW - thiol pKa

U2 - 10.1002/cbic.201600228

DO - 10.1002/cbic.201600228

M3 - Letter

VL - 17

SP - 1689

EP - 1692

JO - ChemBioChem

JF - ChemBioChem

SN - 1439-4227

IS - 18

ER -

Thiol redox and pKa properties of mycothiol, the predomiant low molecular weight thiol cofactor in the Actinomycetes

Abstract

Keywords

Access to Document

Embargoed Document

Projects

Methods for Analysing "Invisible" Cellular Disulfides

Cite this