Thirty years of resistance: Zig-zag through the plant immune system

Bruno Pok Man Ngou, Pingtao Ding, Jonathan D. G. Jones

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Abstract

Understanding the plant immune system is crucial for using genetics to protect crops from diseases. Plants resist pathogens via a two-tiered innate immune detection-and-response system. The first plant Resistance (R) gene was cloned in 1992 (Johal and Briggs, 1992). Since then, many cell-surface pattern recognition receptors (PRRs) have been identified, and R genes that encode intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) have been cloned. Here, we provide a list of characterized PRRs and NLRs. In addition to immune receptors, many components of immune signaling networks were discovered over the last 30 years. We review the signaling pathways, physiological responses, and molecular regulation of both PRR- and NLR-mediated immunity. Recent studies have reinforced the importance of interactions between the two immune systems. We provide an overview of interactions between PRR- and NLR-mediated immunity, highlighting challenges and perspectives for future research.
Original languageEnglish
Pages (from-to)1447–1478
Number of pages32
JournalThe Plant Cell
Volume34
Issue number5
Early online date15 Feb 2022
DOIs
Publication statusPublished - May 2022

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