Abstract
Nitrogen-containing heterocycles represent a major source of pharmacological probes and drug candidates. To extend their molecular diversity and their potential biological activities, it is of importance to design and synthesize new N-heterocyclic scaffolds. Therefore, aza-diketopiperazines (aza-DKPs), the aza analogues of well-known 2,5-diketopiperazines (DKPs), emerged as a promising new scaffold. Although the first synthesis of an aza-DKP dates from 1951, significant developments have been made during the last decade. This feature article summarizes the different synthetic strategies to access and functionalise aza-DKPs. Their biological properties and potential applications in medicinal chemistry and drug discovery are discussed as well.
Original language | English |
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Pages (from-to) | 43358-43370 |
Number of pages | 13 |
Journal | RSC Advances |
Volume | 10 |
Issue number | 71 |
Early online date | 7 Dec 2020 |
DOIs | |
Publication status | Published - 2020 |
Profiles
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A. Ganesan
- School of Chemistry, Pharmacy and Pharmacology - Professor in Chemical Biology
Person: Academic, Teaching & Research