TY - JOUR
T1 - To cool or not to cool? Hypothermia treatment outside trial criteria
AU - Austin, Topun
AU - Shanmugalingam, Shanthi
AU - Clarke, Paul
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Most infants undergoing therapeutic hypothermia for hypoxic-ischaemic encephalopathy fit the clinical criteria used in the main randomised controlled trials. Many infants who would not strictly have qualified for trial entry may nevertheless benefit from hypothermia. These may include infants presenting with postnatal collapse, infants with neonatal stroke and moderately preterm infants. Given the relative safety and potential lifelong benefits of hypothermia treatment, all patients who may benefit from cooling should receive it in a timely and consistent manner. This article reviews several clinical scenarios where cooling may be considered for neuroprotection and provides practical management guidance based on available evidence. The authors emphasise the importance of clear communication with parents and of maintaining national registers to record practices.
AB - Most infants undergoing therapeutic hypothermia for hypoxic-ischaemic encephalopathy fit the clinical criteria used in the main randomised controlled trials. Many infants who would not strictly have qualified for trial entry may nevertheless benefit from hypothermia. These may include infants presenting with postnatal collapse, infants with neonatal stroke and moderately preterm infants. Given the relative safety and potential lifelong benefits of hypothermia treatment, all patients who may benefit from cooling should receive it in a timely and consistent manner. This article reviews several clinical scenarios where cooling may be considered for neuroprotection and provides practical management guidance based on available evidence. The authors emphasise the importance of clear communication with parents and of maintaining national registers to record practices.
UR - http://www.scopus.com/inward/record.url?scp=84883487167&partnerID=8YFLogxK
U2 - 10.1136/archdischild-2012-302069
DO - 10.1136/archdischild-2012-302069
M3 - Review article
C2 - 22820487
AN - SCOPUS:84883487167
VL - 98
SP - F451-F453
JO - Archives of Disease in Childhood: Fetal & Neonatal Edition
JF - Archives of Disease in Childhood: Fetal & Neonatal Edition
SN - 1359-2998
IS - 5
ER -