Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid

Sharmistha Das; Hasina Yasmin; M. Mehedi Masud; Suvas C. Roy; Lutfun Nahar; M. Mukhlesur Rahman; Simon Gibbons; Sitesh C. Bachar; Satyajit D. Sarker

doi:10.1016/j.tet.2008.07.010

Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid

Sharmistha Das, Hasina Yasmin, M. Mehedi Masud, Suvas C. Roy, Lutfun Nahar, M. Mukhlesur Rahman, Simon Gibbons, Sitesh C. Bachar, Satyajit D. Sarker

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3-fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6-fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid induced writhing in Swiss albino mice.

Original language	English
Pages (from-to)	8642-8645
Number of pages	4
Journal	Tetrahedron
Volume	64
Issue number	37
DOIs	https://doi.org/10.1016/j.tet.2008.07.010
Publication status	Published - 8 Sep 2008

Access to Document

10.1016/j.tet.2008.07.010

https://linkinghub.elsevier.com/retrieve/pii/S0040402008012623

Cite this

@article{38ecb2928cea43048582edb2c52b52e0,

title = "Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid",

abstract = "6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3-fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6-fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid induced writhing in Swiss albino mice.",

author = "Sharmistha Das and Hasina Yasmin and Masud, {M. Mehedi} and Roy, {Suvas C.} and Lutfun Nahar and Rahman, {M. Mukhlesur} and Simon Gibbons and Bachar, {Sitesh C.} and Sarker, {Satyajit D.}",

year = "2008",

month = sep,

day = "8",

doi = "10.1016/j.tet.2008.07.010",

language = "English",

volume = "64",

pages = "8642--8645",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier",

number = "37",

}

TY - JOUR

T1 - Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid

AU - Das, Sharmistha

AU - Yasmin, Hasina

AU - Masud, M. Mehedi

AU - Roy, Suvas C.

AU - Nahar, Lutfun

AU - Rahman, M. Mukhlesur

AU - Gibbons, Simon

AU - Bachar, Sitesh C.

AU - Sarker, Satyajit D.

PY - 2008/9/8

Y1 - 2008/9/8

N2 - 6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3-fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6-fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid induced writhing in Swiss albino mice.

AB - 6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3-fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6-fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid induced writhing in Swiss albino mice.

U2 - 10.1016/j.tet.2008.07.010

DO - 10.1016/j.tet.2008.07.010

M3 - Article

VL - 64

SP - 8642

EP - 8645

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 37

ER -