Abstract
6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3-fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6-fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid induced writhing in Swiss albino mice.
Original language | English |
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Pages (from-to) | 8642-8645 |
Number of pages | 4 |
Journal | Tetrahedron |
Volume | 64 |
Issue number | 37 |
DOIs | |
Publication status | Published - 8 Sept 2008 |