Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid

Sharmistha Das, Hasina Yasmin, M. Mehedi Masud, Suvas C. Roy, Lutfun Nahar, M. Mukhlesur Rahman, Simon Gibbons, Sitesh C. Bachar, Satyajit D. Sarker

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8 Citations (Scopus)


6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3-fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6-fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid induced writhing in Swiss albino mice.
Original languageEnglish
Pages (from-to)8642-8645
Number of pages4
Issue number37
Publication statusPublished - 8 Sep 2008

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