Abstract
Three diastereomers of burkholdac B were prepared by total synthesis, enabling the full stereochemical assignment of the natural product. It is proposed that burkholdac B is identical to thailandepsin A independently isolated by Cheng from the same strain of Burkholderia thailandensis. Burkholdac B is the most potent among depsipeptide histone deacetylase inhibitors in growth inhibition of the MCF7 breast cancer cell line with an IC50 of 60 pM. © 2011 American Chemical Society.
Original language | English |
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Pages (from-to) | 6334-6337 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 13 |
Issue number | 24 |
DOIs | |
Publication status | Published - 2011 |