Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator

Anna C. Silva, Hanae Benelkebir, Rosangela S. C. Lopes, Claudio C. Lopes, A Ganesan

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Abstract

The total synthesis of the plant natural product altissimacoumarin D was achieved
by the Mitsunobu alkylation of isofraxidin by geraniol. Isofraxidin was prepared from 2,4-dihydroxybenzaldehyde in five steps. The key reaction was the Knoevenagel condensation of an ortho-hydroxybenzaldehyde with Meldrum’s acid under neutral conditions in water and one-pot acid catalyzed cyclization to the coumarin.
Original languageEnglish
Pages (from-to)1157-1161
Number of pages5
JournalJournal of the Brazilian Chemical Society
Volume29
Issue number5
DOIs
Publication statusPublished - 9 Feb 2018

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