Total synthesis of altissimacoumarin D, a small molecule sirtuin1 activator

Anna C. Silva, Hanae Benelkebir, Rosangela S. C. Lopes, Claudio C. Lopes, A. Ganesan

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
17 Downloads (Pure)


The total synthesis of the plant natural product altissimacoumarin D was achieved by the Mitsunobu alkylation of isofraxidin by geraniol. Isofraxidin was prepared from 2,4-dihydroxybenzaldehyde in five steps. The key reaction was the Knoevenagel condensation of an ortho-hydroxybenzaldehyde with Meldrum’s acid under neutral conditions in water and one-pot acid catalyzed cyclization to the coumarin.
Original languageEnglish
Pages (from-to)1157-1161
Number of pages5
JournalJournal of the Brazilian Chemical Society
Issue number5
Publication statusPublished - 9 Feb 2018

Cite this