Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

Shijun Wen, Krystle L. Carey, Yoichi Nakao, Nobuhiro Fusetani, Graham Packham, A. Ganesan

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

The unprecedented diastereoselective Mannich reaction of a Z-allylsulfoximine was a key step in the total synthesis of the marine natural products azumamide A and E, and an unnatural analogue. Their relative potency as histone deacetylase inhibitors was evaluated and found to correlate with predicted zinc-binding affinity.
Original languageEnglish
Pages (from-to)1105-1108
Number of pages4
JournalOrganic Letters
Volume9
Issue number6
DOIs
Publication statusPublished - 1 Mar 2007

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